Aikawa-Aikawa Laboratories

Singh SA, Aikawa E, Aikawa M

Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research.

Circ J. 2016;80(8):1674-83 - PMID: 27430298 - DOI: 10.1253/circj.CJ-16-0499

Nakano Y, Matoba T, Tokutome M, Funamoto D, Katsuki S, Ikeda G, Nagaoka K, Ishikita A, Nakano K, Koga J, Sunagawa K, Egashira K

Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.

Sci Rep. 2016;6:29601 - PMID: 27403534 - PMCID: PMC4939605 - DOI: 10.1038/srep29601

Nakano T, Fukuda D, Koga JI, Aikawa M

Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.

Arterioscler Thromb Vasc Biol. 2016;36(10):2038-47 - PMID: 27562914 - PMCID: PMC5033717 - DOI: 10.1161/ATVBAHA.116.306926

Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.

Cell Stem Cell. 2016;19(5):628-642 - PMID: 27618218 - PMCID: PMC5097006 - DOI: 10.1016/j.stem.2016.08.001

Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.

Nat Commun. 2016;7:12849 - PMID: 27796300 - PMCID: PMC5095532 - DOI: 10.1038/ncomms12849

Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko P, Guerrero J, Dal-Bianco J, Beaudoin J, Garcia M, Sullivan S, Seybolt M, Morris B, Keegan J, Irvin W, Aikawa E, Levine R

CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction.

Circ Res. 2016;119(11):1215-1225 - PMID: 27750208 - PMCID: PMC5215059 - DOI: 10.1161/CIRCRESAHA.116.309598

Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA

Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins.

Proteomics. 2016;:ePub - PMID: 27862954 - PMCID: PMC5572145 - DOI: 10.1002/pmic.201600085

Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E

Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.

Front Cardiovasc Med. 2016;3:44 - PMID: 27867942 - PMCID: PMC5095138 - DOI: 10.3389/fcvm.2016.00044

Takase S, Matoba T, Nakashiro S, Mukai Y, Inoue S, Oi K, Higo T, Katsuki S, Takemoto M, Suematsu N, Eshima K, Miyata K, Yamamoto M, Usui M, Sadamatsu K, Satoh S, Kadokami T, Hironaga K, Ichi I, Todaka K, Kishimoto J, Egashira K, Sunagawa K.

Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial.

Arterioscler Thromb Vasc Biol. 2016;37(2):350-358 - PMID: 27932353 - DOI: 10.1161/ATVBAHA.116.308388

Singh SA, Aikawa M

Unbiased and targeted mass spectrometry for the HDL proteome.

Curr Opin Lipidol. 2016;28(1):68-77 - PMID: 28002079 - PMCID: PMC6211176 - DOI: 10.1097/MOL.0000000000000374

van der Ven CF, Wu PJ, Tibbitt MW, van Mil A, Sluijter JP, Langer R, Aikawa E

In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease.

Clin Sci (Lond). 2017;131(3):181-195 - PMID: 28057890 - PMCID: PMC5459552 - DOI: 10.1042/CS20160378

Hutcheson JD, Blaser MC, Aikawa E

Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field.

Circ Res. 2017;120(2):270-273 - PMID: 28104767 - PMCID: PMC5260841 - DOI: 10.1161/CIRCRESAHA.116.310060

Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E

Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men.

Arterioscler Thromb Vasc Biol. 2017;37(5):1005-1011 - PMID: 28279970 - PMCID: PMC5407935 - DOI: 10.1161/ATVBAHA.116.308932

Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E

Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.

Semin Thorac Cardiovasc Surg. 2016;28(4):757-767 - PMID: 28417861 - DOI: 10.1053/j.semtcvs.2016.08.015

Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E

Interferon-? Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.

Am J Pathol. 2017;187(6):1413-1425 - PMID: 28431214 - PMCID: PMC5455058 - DOI: 10.1016/j.ajpath.2017.02.012

Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce K, Libby P

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice - Implications for Superficial Erosion.

Circ Res. 2017;121(1):31-42 - PMID: 28428204 - PMCID: PMC5488735 - DOI: 10.1161/CIRCRESAHA.117.310694

Aikawa E, Libby P

A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis.

Circulation. 2017;135(20):1951-1955 - PMID: 28507250 - PMCID: PMC5479353 - DOI: 10.1161/CIRCULATIONAHA.117.027776

Rogers M, Maldonado-Martinez N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E

Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.

Circ Res. 2017;121(3):220-233 - PMID: 28607103 - PMCID: PMC5546003 - DOI: 10.1161/CIRCRESAHA.116.310293

Tadokoro T, Katsuki S, Ito K, Onitsuka K, Nakashima A, Sasaguri T, Miyata K, Yamamoto H, Mohri M

Inoperable Primary Ovarian Carcinoid Led to the Progression of Carcinoid Heart Disease From Right-Sided to Both-Sided Involvement.

Circ Heart Fail. 2017;10(1):ePub - PMID: 28069686 - DOI: 10.1161/CIRCHEARTFAILURE.116.003719

Kawakami R, Matsumoto I, Shiomi M, Kurozumi M, Miyake Y, Ishizawa M, Ishikawa K, Murakami K, Noma T, Takagi Y, Nishimoto N, Minamino T

Role of the Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio in Predicting Serial Changes in the Lipid Component of Coronary Plaque.

Circ J. 2017;81(10):1439-1446 - PMID: 28458377 - DOI: 10.1253/circj.CJ-16-1209

Kawakami R, Nakagami H, Noma T, Ohmori K, Kohno M, Morishita R.

RANKL system in vascular and valve calcification with aging

Inflammation and Regeneration. 2016;36:10

Rogers MA, Aikawa M, Aikawa E

Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.

Circ Res. 2017;121(1):5-7 - PMID: 28642321 - PMCID: PMC5507366 - DOI: 10.1161/CIRCRESAHA.117.311219

Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA,

Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.

J Am Coll Cardiol. 2017;70(10):1232-1244 - PMID: 28859786 - PMCID: PMC5679094 - DOI: 10.1016/j.jacc.2017.07.734

Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ

New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.

Eur Heart J. 2017;39(15):1269-1277 - PMID: 29020406 - PMCID: PMC5905589 - DOI: 10.1093/eurheartj/ehx505

Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA

Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling.

Circ Cardiovasc Imaging. 2017;10(11):ePub - PMID: 29042413 - PMCID: PMC5683411 - DOI: 10.1161/CIRCIMAGING.117.006512

Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH

Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.

Eur Heart J. 2017;39(28):2618-2624 - PMID: 29136138 - PMCID: PMC6055545 - DOI: 10.1093/eurheartj/ehx653

Goettsch C, Kjolby M, Aikawa E

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.

Arterioscler Thromb Vasc Biol. 2017;38(1):19-25 - PMID: 29191923 - PMCID: PMC5746432 - DOI: 10.1161/ATVBAHA.117.310292

Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK

Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation.

JACC Cardiovasc Imaging. 2017;12(4):665-677 - PMID: 29248661 - PMCID: PMC5993562 - DOI: 10.1016/j.jcmg.2017.09.013

Katsuki S, Matoba T, Koga JI, Nakano K, Egashira K

Anti-inflammatory Nanomedicine for Cardiovascular Disease.

Front Cardiovasc Med. 2017;4:87 - PMID: 29312961 - PMCID: PMC5743792 - DOI: 10.3389/fcvm.2017.00087

Sena BF, Figueiredo JL, Aikawa E

Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease.

Front Cardiovasc Med. 2018;4:88 - PMID: 29379789 - PMCID: PMC5770806 - DOI: 10.3389/fcvm.2017.00088

Itoh S, Mizuno K, Aikawa M, Aikawa E

Dimerization of sortilin regulates its trafficking to extracellular vesicles.

J Biol Chem. 2018;293(12):4532-4544 - PMID: 29382723 - PMCID: PMC5868269 - DOI: 10.1074/jbc.RA117.000732

Hutcheson JD, Aikawa E

Extracellular vesicles in cardiovascular homeostasis and disease.

Curr Opin Cardiol. 2018;33(3):290-297 - PMID: 29465447 - PMCID: PMC5895489 - DOI: 10.1097/HCO.0000000000000510

Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Int J Mol Sci. 2018;19(3):ePub - PMID: 29495441 - PMCID: PMC5877524 - DOI: 10.3390/ijms19030663

Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM

Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction.

Ann Thorac Surg. 2018;105(6):1809-1818 - PMID: 29510094 - PMCID: PMC6292668 - DOI: 10.1016/j.athoracsur.2018.01.076

Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E

Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.

Circulation. 2018;138(4):377-393 - PMID: 29588317 - PMCID: PMC6160370 - DOI: 10.1161/CIRCULATIONAHA.117.032291

Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA

Mitral Valve Adaptation: Can We Win the Race?

Circ Cardiovasc Imaging. 2018;11(4):e007642 - PMID: 29626080 - PMCID: PMC5890943 - DOI: 10.1161/CIRCIMAGING.118.007642

Fujino T, Inoue S, Katsuki S, Higo T, Ide T, Oda Y, Tsutsui H

Fatal Cardiac Hemochromatosis in a Patient with Hereditary Spherocytosis.

Int Heart J. 2018;59(2):427-430 - PMID: 29563373 - DOI: 10.1536/ihj.17-160

van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.

Nanomaterials (Basel). 2018;8(5):ePub - PMID: 29751516 - PMCID: PMC5977310 - DOI: 10.3390/nano8050296

Lei Y, Lei L, Wang Y, Singh SA, Aikawa E

TEMPORARY REMOVAL: Catalytically inactive phosphatase MTMR12 is a novel regulator of osteoclast function through F-actin ring formation.

Biochim Biophys Acta. 2018;:ePub - PMID: 29902551 - DOI: 10.1016/j.bbadis.2018.06.008

Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E

Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.

Sci Rep. 2018;8(1):9006 - PMID: 29899496 - PMCID: PMC5998044 - DOI: 10.1038/s41598-018-27416-y

Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.

NPJ Syst Biol Appl. 2018;4:25 - PMID: 29977601 - PMCID: PMC6028434 - DOI: 10.1038/s41540-018-0057-0

Sen DG, Halu A, Razzaque M, Gorham JM, Hartnett J, Seidman JG, Aikawa E, Seidman CE

The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development.

Ann Thorac Surg. 2018;106(6):1834-1840 - PMID: 30071238 - DOI: 10.1016/j.athoracsur.2018.06.034

Decano JL, Aikawa M

Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease.

Front Cardiovasc Med. 2018;5:97 - PMID: 30123798 - PMCID: PMC6086112 - DOI: 10.3389/fcvm.2018.00097

Dekker S, van Geemen D, van den Bogaerdt AJ, Driessen-Mol A, Aikawa E, Smits AIPM

Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves.

Front Cardiovasc Med. 2018;5:105 - PMID: 30159315 - PMCID: PMC6104173 - DOI: 10.3389/fcvm.2018.00105

Lee LH, Halu A, Morgan S, Iwata H, Aikawa M, Singh SA

XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis.

J Proteome Res. 2018;18(2):775-781 - PMID: 30370770 - DOI: 10.1021/acs.jproteome.8b00615

Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A

Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.

Elife. 2018;7:ePub - PMID: 30303482 - PMCID: PMC6179386 - DOI: 10.7554/eLife.37059

Koenen RR, Aikawa E

Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases.

Front Cardiovasc Med. 2018;5:133 - PMID: 30283791 - PMCID: PMC6157324 - DOI: 10.3389/fcvm.2018.00133

Rogers MA, Aikawa E

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.

Nat Rev Cardiol. 2018;16(5):261-274 - PMID: 30531869 - DOI: 10.1038/s41569-018-0123-8

Kawakami R, Nozato Y, Nakagami H, Ikeda Y, Shimamura M, Yoshida S, Sun J, Kawano T, Takami Y, Noma T, Rakugi H, Minamino T, Morishita R

Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice.

PLoS One. 2018;13(2):e0191895 - PMID: 29438441 - PMCID: PMC5811007 - DOI: 10.1371/journal.pone.0191895

Passos LS, Gazzinelli-Guimarães PH, Oliveira Mendes TA, Guimarães AC, Silveira Lemos DD, Ricci ND, Gonçalves R, Bartholomeu DC, Fujiwara RT, Bueno LL

Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection.

BMC Infect Dis. 2017;17(1):253 - PMID: 28390393 - PMCID: PMC5385058 - DOI: 10.1186/s12879-017-2366-0