Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital
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Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
J Biomed Opt. 2006;11(2):021009 - PMID: 16674184 - DOI: 10.1117/1.2186337
Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
Circulation. 2006;113(19):2301-12 - PMID: 16682613 - DOI: 10.1161/CIRCULATIONAHA.105.605121
Jaffer FA, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R
Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials.
Mol Imaging. 2006;5(2):85-92 - PMID: 16954022
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proc Natl Acad Sci U S A. 2006;103(27):10340-10345 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103
Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.
Circulation. 2006;114(14):1504-11 - PMID: 17000904 - DOI: 10.1161/CIRCULATIONAHA.106.646380
Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.
Circ Res. 2006;99(8):861-9 - PMID: 16973908 - PMCID: PMC2810464 - DOI: 10.1161/01.RES.0000245188.41002.2c
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.
Circulation. 2007;115(3):377-86 - PMID: 17224478 - DOI: 10.1161/CIRCULATIONAHA.106.654913
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.
J Clin Invest. 2007;117(1):195-205 - PMID: 17200719 - PMCID: PMC1716211 - DOI: 10.1172/JCI29950
Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V
Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo.
Circulation. 2007;115(11):1384-91 - PMID: 17339546 - DOI: 10.1161/CIRCULATIONAHA.106.663351
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor.
Circulation. 2007;115(17):2292-8 - PMID: 17420353 - DOI: 10.1161/CIRCULATIONAHA.106.660340
Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.
Circ Res. 2007;100(8):1218-25 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31
Mendelson K, Aikawa E, Mettler BA, Sales V, Martin D, Mayer JE, Schoen FJ
Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep.
Cardiovasc Pathol. 2007;16(5):277-82 - PMID: 17868878 - DOI: 10.1016/j.carpath.2007.03.008
Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517 - DOI: 10.1084/jem.20070885
Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.
Circulation. 2007;117(3):379-87 - PMID: 18158358 - PMCID: PMC2663426 - DOI: 10.1161/CIRCULATIONAHA.107.741181
Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain. 2008;131(Pt 4):1123-33 - PMID: 18234693 - PMCID: PMC4044727 - DOI: 10.1093/brain/awn004
Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R
Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.
Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051 - DOI: 10.1161/CIRCULATIONAHA.107.756510
Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis.
Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441 - DOI: 10.1161/CIRCULATIONAHA.108.785881
Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L
Simplified syntheses of complex multifunctional nanomaterials.
Chem Commun (Camb). 2008;(39):4792-4 - PMID: 18830495 - PMCID: PMC2692914 - DOI: 10.1039/b809537j
Breckwoldt MO, Chen JW, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz MA, Weissleder R
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.
Proc Natl Acad Sci U S A. 2008;105(47):18584-9 - PMID: 19011099 - PMCID: PMC2587593 - DOI: 10.1073/pnas.0803945105
Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
Proc Natl Acad Sci U S A. 2008;105(49):19126-31 - PMID: 19015534 - PMCID: PMC2614726 - DOI: 10.1073/pnas.0804798105
Rusanescu G, Weissleder R, Aikawa E
Notch signaling in cardiovascular disease and calcification.
Curr Cardiol Rev. 2008;4(3):148-56 - PMID: 19936191 - PMCID: PMC2780816 - DOI: 10.2174/157340308785160552
McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Neuroimage. 2008;45(2):360-9 - PMID: 19154791 - PMCID: PMC2707831 - DOI: 10.1016/j.neuroimage.2008.12.022
Christen T, Nahrendorf M, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P
Molecular imaging of innate immune cell function in transplant rejection.
Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889 - DOI: 10.1161/CIRCULATIONAHA.108.796888
Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.
Integr Biol (Camb). 2009;1(4):311-7 - PMID: 20023731 - PMCID: PMC2748356 - DOI: 10.1039/b821775k
Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ, Wedeen VJ
Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium.
Circ Cardiovasc Imaging. 2009;2(3):206-12 - PMID: 19808594 - PMCID: PMC2760045 - DOI: 10.1161/CIRCIMAGING.108.815050
Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L
The antiproliferative cytostatic effects of a self-activating viridin prodrug.
Mol Cancer Ther. 2009;8(6):1666-75 - PMID: 19509266 - PMCID: PMC2740925 - DOI: 10.1158/1535-7163.MCT-08-1012
Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA, Carpentier A
Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation.
Circulation. 2009;120(4):334-42 - PMID: 19597052 - PMCID: PMC2752046 - DOI: 10.1161/CIRCULATIONAHA.108.846782
Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R
Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.
Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251 - DOI: 10.1161/ATVBAHA.109.193086
Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ
Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
Science. 2009;325(5940):612-6 - PMID: 19644120 - PMCID: PMC2803111 - DOI: 10.1126/science.1175202
Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A
Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.
Circ Cardiovasc Imaging. 2009;2(6):468-75 - PMID: 19920045 - PMCID: PMC2782621 - DOI: 10.1161/CIRCIMAGING.109.863779
Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.
JACC Cardiovasc Imaging. 2009;2(10):1213-22 - PMID: 19833312 - PMCID: PMC2773129 - DOI: 10.1016/j.jcmg.2009.04.016
Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L
Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.
Circ Cardiovasc Imaging. 2009;2(6):460-7 - PMID: 19920044 - PMCID: PMC2780438 - DOI: 10.1161/CIRCIMAGING.109.859678
Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA
Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.
J Am Chem Soc. 2009;131(43):15739-44 - PMID: 19817443 - PMCID: PMC2773134 - DOI: 10.1021/ja903922u
Sales VL, Mettler BA, Engelmayr GC, Aikawa E, Bischoff J, Martin DP, Exarhopoulos A, Moses MA, Schoen FJ, Sacks MS, Mayer JE
Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves.
Tissue Eng Part A. 2010;16(1):257-67 - PMID: 19698056 - PMCID: PMC2811057 - DOI: 10.1089/ten.TEA.2009.0424
Ramaswamy S, Gottlieb D, Engelmayr GC, Aikawa E, Schmidt DE, Gaitan-Leon DM, Sales VL, Mayer JE, Sacks MS
The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells.
Biomaterials. 2009;31(6):1114-25 - PMID: 19944458 - PMCID: PMC2813971 - DOI: 10.1016/j.biomaterials.2009.10.019
Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer JE, Aikawa E
Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study.
Tissue Eng Part C Methods. 2010;16(4):597-607 - PMID: 19751103 - PMCID: PMC7875113 - DOI: 10.1089/ten.TEC.2009.0466
Gottlieb D, Kunal T, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC, Melero-Martin JM, Sacks MS, Mayer JE
In vivo monitoring of function of autologous engineered pulmonary valve.
J Thorac Cardiovasc Surg. 2010;139(3):723-31 - PMID: 20176213 - DOI: 10.1016/j.jtcvs.2009.11.006
Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089
Norris RA, Moreno-Rodriguez R, Wessels A, Merot J, Bruneval P, Chester AH, Yacoub MH, Hagège A, Slaugenhaupt SA, Aikawa E, Schott JJ, Lardeux A, Harris BS, Williams LK, Richards A, Levine RA, Markwald RR
Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis.
Dev Dyn. 2010;239(7):2118-27 - PMID: 20549728 - PMCID: PMC2909582 - DOI: 10.1002/dvdy.22346
Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.
Eur Heart J. 2010;31(16):1975-84 - PMID: 20601388 - PMCID: PMC2921509 - DOI: 10.1093/eurheartj/ehq237
Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA
Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.
Arterioscler Thromb Vasc Biol. 2010;30(10):1933-9 - PMID: 20689078 - PMCID: PMC3030475 - DOI: 10.1161/ATVBAHA.110.206342
Wylie-Sears J, Aikawa E, Levine RA, Yang JH, Bischoff J
Mitral valve endothelial cells with osteogenic differentiation potential.
Arterioscler Thromb Vasc Biol. 2010;31(3):598-607 - PMID: 21164078 - PMCID: PMC3210435 - DOI: 10.1161/ATVBAHA.110.216184
Brokopp CE, Schoenauer R, Richards P, Bauer S, Lohmann C, Emmert MY, Weber B, Winnik S, Aikawa E, Graves K, Genoni M, Vogt P, Lüscher TF, Renner C, Hoerstrup SP, Matter CM
Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata.
Eur Heart J. 2011;32(21):2713-22 - PMID: 21292680 - PMCID: PMC3205479 - DOI: 10.1093/eurheartj/ehq519
Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA
Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.
Sci Transl Med. 2011;3(84):84ra45 - PMID: 21613624 - PMCID: PMC3112179 - DOI: 10.1126/scitranslmed.3001577
Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.
Nat Med. 2011;17(9):1142-6 - PMID: 21857652 - PMCID: PMC3169740 - DOI: 10.1038/nm.2423
Bischoff J, Aikawa E
Progenitor cells confer plasticity to cardiac valve endothelium.
J Cardiovasc Transl Res. 2011;4(6):710-9 - PMID: 21789724 - DOI: 10.1007/s12265-011-9312-0
New SE, Aikawa E
Cardiovascular calcification: an inflammatory disease.
Circ J. 2011;75(6):1305-13 - PMID: 21566338 - DOI: 10.1253/circj.cj-11-0395
New SE, Aikawa E
Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification.
Circ Res. 2011;108(11):1381-91 - PMID: 21617135 - PMCID: PMC3139950 - DOI: 10.1161/CIRCRESAHA.110.234146
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM
Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.
Circulation. 2011;124(16):1783-91 - PMID: 22007101 - PMCID: PMC3306614 - DOI: 10.1161/CIRCULATIONAHA.110.006767
Su HS, Nahrendorf M, Panizzi P, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW
Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.
Radiology. 2011;262(1):181-90 - PMID: 22084204 - PMCID: PMC3244672 - DOI: 10.1148/radiol.11110040
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