Aikawa-Aikawa Laboratories

Martinez-Martinez, Eduardo

Research Fellow

(617) 525-4386

EMARTINEZ@research.bwh.harvard.edu

Dr. Eduardo Martínez Martínez obtained his PhD in Neurobiology from the Universidad Nacional Autónoma de Mexico. During his doctoral research in the laboratory of Dr. Gabriel Gutiérrez Ospina, he investigated the functional role of sensory innervation during wound healing. After his graduation, Dr. Martínez joined a multidisciplinary group that analyses the development of science, technology and innovation in Mexico at The Science and Technology Advisory Forum.
Dr. Martínez joined the group of Dr. Elena Aikawa in January 2013 to study the cellular mechanisms that underlie calcific aortic valve disease. He focuses on understanding the role of extracellular vesicles as precursors of microcalcifications in the aortic valve.

Publications

Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-? Signaling.

Arterioscler Thromb Vasc Biol. 2016;36(3):525-33 - PMID: 26800565 - PMCID: PMC4767541 - DOI: 10.1161/ATVBAHA.115.307009

Fetter-Pruneda I, Geovannini-Acuña H, Santiago C, Ibarrarán-Viniegra AS, Martínez-Martínez E, Sandoval-Velasco M, Uribe-Figueroa L, Padilla-Cortés P, Mercado-Célis G, Gutiérrez-Ospina G

Shifts in developmental timing, and not increased levels of experience-dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth.

PLoS One. 2013;8(1):e54940 - PMID: 23372796 - PMCID: PMC3556040 - DOI: 10.1371/journal.pone.0054940

Martínez-Martínez E, Zaragoza ML, Solano E, Figueroa B, Zúñiga P, Laclette JP

Health research funding in Mexico: the need for a long-term agenda.

PLoS One. 2012;7(12):e51195 - PMID: 23251451 - PMCID: PMC3519634 - DOI: 10.1371/journal.pone.0051195

Martínez-Martínez E, Galván-Hernández CI, Toscano-Márquez B, Gutiérrez-Ospina G

Modulatory role of sensory innervation on hair follicle stem cell progeny during wound healing of the rat skin.

PLoS One. 2012;7(5):e36421 - PMID: 22574159 - PMCID: PMC3344885 - DOI: 10.1371/journal.pone.0036421

Martínez-Martínez E, Toscano-Márquez B, Gutiérrez-Ospina G

Long-term effects of neonatal capsaicin treatment on intraepidermal nerve fibers and keratinocyte proliferation in rat glabrous skin.

Anat Rec (Hoboken). 2010;294(1):173-84 - PMID: 21157928 - DOI: 10.1002/ar.21237

Toscano-Márquez B, Martínez-Martínez E, Manjarrez E, Martínez L, Mendoza-Torreblanca J, Gutiérrez-Ospina G

Late onset muscle plasticity in the whisker pad of enucleated rats.

Proc Natl Acad Sci U S A. 2008;105(41):15973-8 - PMID: 18838691 - PMCID: PMC2572979 - DOI: 10.1073/pnas.0808431105

Mendoza-Torreblanca JG, Martínez-Martínez E, Tapia-Rodríguez M, Ramírez-Hernández R, Gutiérrez-Ospina G

The rostral migratory stream is a neurogenic niche that predominantly engenders periglomerular cells: in vivo evidence in the adult rat brain.

Neurosci Res. 2007;60(3):289-99 - PMID: 18243385 - DOI: 10.1016/j.neures.2007.11.013

Uribe-Querol E, Martínez-Martínez E, Tapia-Rodríguez M, Hernández LR, Toscano-Márquez B, Padilla P, Gutiérrez-Ospina G

Metabolic indices shift in the hypothalamic-neurohypophysial system during lactation: implications for interpreting their relationship with neuronal activity.

Neuroscience. 2005;134(4):1217-22 - PMID: 16054766 - DOI: 10.1016/j.neuroscience.2005.05.059

Zomosa-Signoret V, Hernández-Alcántara G, Reyes-Vivas H, Martínez-Martínez E, Garza-Ramos G, Pérez-Montfort R, Tuena De Gómez-Puyou M, Gómez-Puyou A

Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers.

Biochemistry. 2003;42(11):3311-8 - PMID: 12641463 - DOI: 10.1021/bi0206560

Reyes-Vivas H, Martínez-Martínez E, Mendoza-Hernández G, López-Velázquez G, Pérez-Montfort R, Tuena de Gómez-Puyou M, Gómez-Puyou A

Susceptibility to proteolysis of triosephosphate isomerase from two pathogenic parasites: characterization of an enzyme with an intact and a nicked monomer.

Proteins. 2002;48(3):580-90 - PMID: 12112681 - DOI: 10.1002/prot.10179