Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital
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Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.
PLoS Pathog. 2019;15(5):e1007756 - PMID: 31095648 - DOI: 10.1371/journal.ppat.1007756
Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR
Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis.
J Am Coll Cardiol. 2019;73(17):2150-2162 - PMID: 31047003 - DOI: 10.1016/j.jacc.2019.01.070
Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E
Standardization of Human Calcific Aortic Valve Disease <i>in vitro</i> Modeling Reveals Passage-Dependent Calcification.
Front Cardiovasc Med. 2019;6:49 - PMID: 31041314 - PMCID: PMC6476921 - DOI: 10.3389/fcvm.2019.00049
Phillippi JA, Aikawa E, Hutcheson J
Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.
Front Cardiovasc Med. 2019;6:13 - PMID: 30873414 - PMCID: PMC6401650 - DOI: 10.3389/fcvm.2019.00013
Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M
A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.
J Proteome Res. 2019;:ePub - PMID: 30848916 - DOI: 10.1021/acs.jproteome.8b00895
Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Front Cardiovasc Med. 2019;6:8 - PMID: 30838213 - PMCID: PMC6382669 - DOI: 10.3389/fcvm.2019.00008
Blaser MC, Aikawa E
Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.
Circ Res. 2019;124(4):467-469 - PMID: 30763209 - PMCID: PMC6383776 - DOI: 10.1161/CIRCRESAHA.119.314596
Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH
Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.
J Am Coll Cardiol. 2019;73(2):190-209 - PMID: 30654892 - DOI: 10.1016/j.jacc.2018.09.089
Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E
18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.
Circ Cardiovasc Imaging. 2019;12(1):e007835 - PMID: 30642216 - PMCID: PMC6338081 - DOI: 10.1161/CIRCIMAGING.118.007835