Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital

Aikawa, Elena

Aikawa, Elena

Director, Vascular Biology Program Professor of Medicine, Harvard Medical School

(617) 730-7755

Dr. Elena Aikawa is a Professor of Medicine at Harvard Medical School and a Principle Investigator at the Center for Excellence in Vascular Biology and Director of the Vascular Biology Program at the Center for Interdisciplinary Sciences at Brigham and Women’s Hospital, Boston, MA, USA. Dr. Aikawa has played a pioneering role in the discovery of inflammation-dependent mechanisms of calcification, and in advocacy for the early imaging and treatment of calcific aortic valve disease. Her current research aim is to develop new therapies to cure calcific aortic valve stenosis, a disease that currently has no treatment except surgical or intercatheter valve replacement.

Dr. Aikawa is a member of the National Heart, Lung, and Blood Institute (NHLBI) Working Group on Calcific Aortic Valve Stenosis and the Alliance of Investigators on Calcific Aortic Valve Disease. She is an Editorial Board Member of Arteriosclerosis, Thrombosis and Vascular Biology , PLoS ONE , Journal of Extracellular Vesicles , and Circulation Research . Dr. Aikawa has delivered over 90 keynote lectures, invited talks and cardiovascular grand rounds, and authored more than 140 manuscripts on cardiovascular pathobiology.

In addition to her strong interest in research, she also enjoys educating and mentoring young scientists. Throughout her career, she has trained a number of research fellows, medical and PhD students. Dr. Aikawa is also committed to advancing the careers of women in science and medicine. She cofounded the Brigham and Women’s Hospital Committee for Internationally Trained Women Faculty in 2004 and founded the annual Women in Medicine and Science Symposium at Brigham and Women’s Hospital in 2012. Dr. Aikawa is a member of the American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology Women’s Leadership Committee .


Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC, Thanassoulis G, Floyd J, Austin TR, Bortnick A, Kizer J, Freitas RCC, Singh SA, Aikawa E, Hoogeveen RC, Ballantyne C, Yu B, Coresh J, Blaha MJ, Matsushita K, Shah AM
Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis.
J Am Coll Cardiol. 2024;83(5):577-591 - PMID: 38296402 - DOI: 10.1016/j.jacc.2023.11.021
Kumar Jha P, Aikawa M, Aikawa E
Macrophage Heterogeneity and Efferocytosis: Beyond the M1/M2 Dichotomy.
Circ Res. 2024;134(2):186-188 - PMID: 38236949 - DOI: 10.1161/CIRCRESAHA.123.324011
Turner ME, Beck L, Hill Gallant KM, Chen Y, Moe OW, Kuro-O M, Moe S, Aikawa E
Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.
Arterioscler Thromb Vasc Biol. 2024;:ePub - PMID: 38205639 - DOI: 10.1161/ATVBAHA.123.319198
Raju S, Botts SR, Blaser MC, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL
Directional Endothelial Communication by Polarized Extracellular Vesicle Release.
Circ Res. 2024;:ePub - PMID: 38174557 - DOI: 10.1161/CIRCRESAHA.123.322993
Hashmi S, Shah PW, Aherrahrou Z, Aikawa E, Aherrahrou R
Beyond the Basics: Unraveling the Complexity of Coronary Artery Calcification.
Cells. 2023;12(24):ePub - PMID: 38132141 - PMCID: PMC10742130 - DOI: 10.3390/cells12242822
Rogers MA, Bartoli-Leonard F, Zheng KH, Small AM, Chen HY, Clift CL, Asano T, Kuraoka S, Blaser MC, Perez KA, Natarajan P, Yeang C, Stroes ESG, Tsimikas S, Engert JC, Thanassoulis G, O'Donnell CJ, Aikawa M, Singh SA, Aikawa E
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.
Circulation. 2023;:ePub - PMID: 37937463 - DOI: 10.1161/CIRCULATIONAHA.123.066822
Yurdagul A, Aikawa E
Discovering a Rare Smooth Muscle Cell Population Specific to Males in Ascending Aortic Aneurysm Using Spatial Transcriptomics.
Arterioscler Thromb Vasc Biol. 2023;:ePub - PMID: 37916413 - DOI: 10.1161/ATVBAHA.123.320235
Turner ME, Aikawa E
Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification.
Cardiovasc Res. 2023;119(13):2259-2261 - PMID: 37875065 - DOI: 10.1093/cvr/cvad139
Decano JL, Maiorino E, Matamalas JT, Chelvanambi S, Tiemeijer BM, Yanagihara Y, Mukai S, Jha PK, Pestana DVS, D'Souza E, Whelan M, Ge R, Asano T, Sharma A, Libby P, Singh SA, Aikawa E, Aikawa M
Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.
Circulation. 2023;:ePub - PMID: 37850387 - DOI: 10.1161/CIRCULATIONAHA.123.064794
Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N
Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.
Commun Biol. 2023;6(1):1017 - PMID: 37805576 - PMCID: PMC10560219 - DOI: 10.1038/s42003-023-05383-z
Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Sacks MS, Mayer JE
Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model.
J Biomed Mater Res A. 2023;:ePub - PMID: 37772456 - DOI: 10.1002/jbm.a.37622
Rouhollahi A, Willi JN, Haltmeier S, Mehrtash A, Straughan R, Javadikasgari H, Brown J, Itoh A, de la Cruz KI, Aikawa E, Edelman ER, Nezami FR
CardioVision: A fully automated deep learning package for medical image segmentation and reconstruction generating digital twins for patients with aortic stenosis.
Comput Med Imaging Graph. 2023;109:102289 - PMID: 37633032 - DOI: 10.1016/j.compmedimag.2023.102289
Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS
PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.
Circ Res. 2023;:ePub - PMID: 37555328 - DOI: 10.1161/CIRCRESAHA.123.323027
Perez KA, Deppe DW, Filas A, Singh SA, Aikawa E
Multimodal analytical tools to enhance mechanistic understanding of aortic valve calcification.
Am J Pathol. 2023;:ePub - PMID: 37517686 - DOI: 10.1016/j.ajpath.2023.06.017
Santinelli-Pestana DV, Aikawa E, Singh SA, Aikawa M
PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages.
Pathogens. 2023;12(7):ePub - PMID: 37513811 - PMCID: PMC10386340 - DOI: 10.3390/pathogens12070964
Blaser MC, Buffolo F, Halu A, Turner ME, Schlotter F, Higashi H, Pantano L, Clift CL, Saddic LA, Atkins SK, Rogers MA, Pham T, Vromman A, Shvartz E, Sukhova GK, Monticone S, Camussi G, Robson SC, Body SC, Muehlschlegel JD, Singh SA, Aikawa M, Aikawa E
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Circulation. 2023;:ePub - PMID: 37427430 - DOI: 10.1161/CIRCULATIONAHA.122.063402
Bartoli-Leonard F, Chelvanambi S, Pham T, Turner ME, Blaser MC, Caputo M, Aikawa M, Pang A, Muehlschlegel J, Aikawa E
Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease.
bioRxiv. 2023;:ePub - PMID: 37461603 - PMCID: PMC10350049 - DOI: 10.1101/2023.07.08.548203
Greco E, Vinciguerra M, Sampaio R, Aikawa E
Editorial: New insights in heart valve disease 2022.
Front Cardiovasc Med. 2023;10:1226113 - PMID: 37416925 - PMCID: PMC10321655 - DOI: 10.3389/fcvm.2023.1226113
Nehl D, Goody PR, Maus K, Pfeifer A, Aikawa E, Bakthiary F, Zimmer S, Nickenig G, Jansen F, Hosen MR
Human and porcine aortic valve endothelial and interstitial cell isolation and characterization.
Front Cardiovasc Med. 2023;10:1151028 - PMID: 37408661 - PMCID: PMC10318150 - DOI: 10.3389/fcvm.2023.1151028
Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL
Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.
bioRxiv. 2023;:ePub - PMID: 37162986 - PMCID: PMC10168399 - DOI: 10.1101/2023.04.28.538787
Veulemans V, Billaud M, Nunes MCP, Goettsch C, Aikawa E
Editorial: Women in heart valve disease.
Front Cardiovasc Med. 2023;10:1150169 - PMID: 36994000 - PMCID: PMC10041336 - DOI: 10.3389/fcvm.2023.1150169
Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O
Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.
Ann N Y Acad Sci. 2023;1523(1):24-37 - PMID: 36961472 - DOI: 10.1111/nyas.14974
Bartoli-Leonard F, Zimmer J, Sonawane AR, Perez K, Turner ME, Kuraoka S, Pham T, Li F, Aikawa M, Singh S, Brewster L, Aikawa E
NLRP3 Inflammasome Activation in Peripheral Arterial Disease.
J Am Heart Assoc. 2023;12(6):e026945 - PMID: 36892058 - PMCID: PMC10111545 - DOI: 10.1161/JAHA.122.026945
Natarajan R, Moore K, Sahoo D, Nana-Sinkam P, Fowler AAB, Sime P, Sorci-Thomas M, Aikawa E, ATVB Council, friends, and colleagues
Shobha Ghosh (1958-2021).
Arterioscler Thromb Vasc Biol. 2023;42(3):239-240 - PMID: 36808997
Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté; N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J
Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.
Nat Rev Cardiol. 2023;:ePub - PMID: 36807395 - DOI: 10.1038/s41569-023-00848-4
Blaser MC, Kraler S, Lüscher TF, Aikawa E
Network-Guided Multiomic Mapping of Aortic Valve Calcification.
Arterioscler Thromb Vasc Biol. 2023;43(3):417-426 - PMID: 36727519 - PMCID: PMC9975082 - DOI: 10.1161/ATVBAHA.122.318334
Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.
Eur Heart J. 2023;44(10):885-898 - PMID: 36660854 - PMCID: PMC9991042 - DOI: 10.1093/eurheartj/ehac818
Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J
The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis.
Nat Rev Cardiol. 2023;:ePub - PMID: 36624274 - DOI: 10.1038/s41569-022-00818-2
Krohn JB, Aikawa E, Aikawa M, Hutcheson JD, Sahoo S, Fish JE
Editorial: Extracellular vesicles in cardiovascular inflammation and calcification.
Front Cardiovasc Med. 2022;9:1077124 - PMID: 36426218 - PMCID: PMC9680153 - DOI: 10.3389/fcvm.2022.1077124
Sutton NR, Malhotra R, Hilaire CS, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y
Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.
Arterioscler Thromb Vasc Biol. 2022;43(1):15-29 - PMID: 36412195 - PMCID: PMC9793888 - DOI: 10.1161/ATVBAHA.122.317332
Corti A, De Paolis A, Grossman P, Dinh PA, Aikawa E, Weinbaum S, Cardoso L
The effect of plaque morphology, material composition and microcalcifications on the risk of cap rupture: A structural analysis of vulnerable atherosclerotic plaques.
Front Cardiovasc Med. 2022;9:1019917 - PMID: 36277774 - PMCID: PMC9583261 - DOI: 10.3389/fcvm.2022.1019917
Katsuki S, Kumar Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, Vittorio Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M
Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.
Circ Res. 2022;131(11):873-889 - PMID: 36263780 - PMCID: PMC9973449 - DOI: 10.1161/CIRCRESAHA.121.320056
Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Ha AH, Wen JR, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP, Singh SA, Aikawa M
Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.
Front Cardiovasc Med. 2022;9:889994 - PMID: 35990960 - PMCID: PMC9382335 - DOI: 10.3389/fcvm.2022.889994
Uchida S, Yu J, Goldman M, Asmis R, Yang X, Aikawa E, Bourantas C, Aikawa M, Tevaearai Stahel H
Editorial: Research reproducibility and preventing fraud.
Front Cardiovasc Med. 2022;9:979467 - PMID: 35979020 - PMCID: PMC9376614 - DOI: 10.3389/fcvm.2022.979467
Atkins SK, Sonawane AR, Brouwhuis R, Barrientos J, Ha A, Rogers M, Tanaka T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E
Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification.
Front Cardiovasc Med. 2022;9:925777 - PMID: 35958427 - PMCID: PMC9357895 - DOI: 10.3389/fcvm.2022.925777
Marsit O, Clavel MA, Paquin A, Deschênes V, Hadjadj S, Sénéchal-Dumais I, Couet J, Arsenault M, Handschumacher MD, Levine RA, Aikawa E, Pibarot P, Beaudoin J
Effects of Cyproheptadine on Mitral Valve Remodeling and Regurgitation After Myocardial Infarction.
J Am Coll Cardiol. 2022;80(5):500-510 - PMID: 35902173 - DOI: 10.1016/j.jacc.2022.05.025
Wang L, Xu GE, Pan L, Aikawa E, Aikawa M, Xiao J, Huang NF
Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021.
Front Cardiovasc Med. 2022;9:928981 - PMID: 35757336 - PMCID: PMC9218798 - DOI: 10.3389/fcvm.2022.928981
Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E
Elevated lipoprotein(a) as a predictor for coronary events in older men.
J Lipid Res. 2022;63(8):100242 - PMID: 35724702 - PMCID: PMC9304778 - DOI: 10.1016/j.jlr.2022.100242
Sonawane AR, Aikawa E, Aikawa M
Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases.
Front Cardiovasc Med. 2022;9:873582 - PMID: 35665246 - PMCID: PMC9160390 - DOI: 10.3389/fcvm.2022.873582
Paquin A, Marsit O, Deschênes V, Rouabhia D, Hadjadj S, Clisson M, Robitaille C, Aikawa E, Levine RA, Pibarot P, Clavel MA, Beaudoin J
Progression of aortic stenosis after an acute myocardial infarction.
Open Heart. 2022;9(1):ePub - PMID: 35728891 - PMCID: PMC9214429 - DOI: 10.1136/openhrt-2022-002046
Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H, Aikawa M
Embracing Diversity, Equity, and Inclusion in the Scientific Community-Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization.
Front Cardiovasc Med. 2022;9:863256 - PMID: 35463765 - PMCID: PMC9021758 - DOI: 10.3389/fcvm.2022.863256
Asano T, Chelvanambi S, Decano JL, Whelan MC, Aikawa E, Aikawa M
In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19.
Front Cardiovasc Med. 2022;9:842641 - PMID: 35402570 - PMCID: PMC8989014 - DOI: 10.3389/fcvm.2022.842641
Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO, Aikawa E, Hung J, Nunes MCP
Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling.
Front Cardiovasc Med. 2022;9:862382 - PMID: 35360029 - PMCID: PMC8962951 - DOI: 10.3389/fcvm.2022.862382
Aikawa E, Hutcheson JD
The Developmental Origin of Calcific Aortic Stenosis.
N Engl J Med. 2022;386(14):1372-1374 - PMID: 35388675 - DOI: 10.1056/NEJMcibr2200439
Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Cell Rep. 2022;39(2):110685 - PMID: 35417712 - DOI: 10.1016/j.celrep.2022.110685
Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E
Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.
Circulation. 2022;145(7):531-548 - PMID: 35157519 - PMCID: PMC8869797 - DOI: 10.1161/CIRCULATIONAHA.121.057301
Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E
Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.
Front Cardiovasc Med. 2022;9:778919 - PMID: 35155626 - PMCID: PMC8831739 - DOI: 10.3389/fcvm.2022.778919
Buffolo F, Monticone S, Camussi G, Aikawa E
Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage.
Hypertension. 2022;79(5):863-873 - PMID: 35144490 - PMCID: PMC9010370 - DOI: 10.1161/HYPERTENSIONAHA.121.17957
Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E
Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification.
Front Cardiovasc Med. 2022;8:826529 - PMID: 35127876 - PMCID: PMC8811128 - DOI: 10.3389/fcvm.2021.826529
Human P, Bezuidenhout D, Aikawa E, Zilla P
Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost.
Front Cardiovasc Med. 2022;8:760635 - PMID: 35059444 - PMCID: PMC8764456 - DOI: 10.3389/fcvm.2021.760635
Kraler S, Blaser MC, Aikawa E, Camici GG, Luscher TF
Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy.
Eur Heart J. 2021;43(7):683-697 - PMID: 34849696 - PMCID: PMC8843796 - DOI: 10.1093/eurheartj/ehab757
van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS
Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel.
Nanoscale. 2021;13(48):20451-20461 - PMID: 34817483 - PMCID: PMC8675028 - DOI: 10.1039/d1nr04973a
Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA
Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.
J Am Heart Assoc. 2021;10(20):e020834 - PMID: 34632804 - PMCID: PMC8751880 - DOI: 10.1161/JAHA.121.020834
Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC
Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease.
Front Cardiovasc Med. 2021;8:687885 - PMID: 34527708 - PMCID: PMC8435633 - DOI: 10.3389/fcvm.2021.687885
Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen P, Ouimet M, Sutton NR, Aikawa E
What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award.
Arterioscler Thromb Vasc Biol. 2021;41(11):2641-2647 - PMID: 34547925 - PMCID: PMC8551033 - DOI: 10.1161/ATVBAHA.121.316558
Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E
Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.
Front Cardiovasc Med. 2021;8:688396 - PMID: 34458332 - PMCID: PMC8387660 - DOI: 10.3389/fcvm.2021.688396
Bartoli-Leonard F, Aikawa E
Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use?
Circ Res. 2021;129(4):491-493 - PMID: 34351800 - PMCID: PMC8352010 - DOI: 10.1161/CIRCRESAHA.121.319721
Bartoli-Leonard F, Aikawa E
Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use?
Circ Res. 2021;129(4):491-493 - PMID: 34351800 - PMCID: PMC8352010 - DOI: 10.1161/CIRCRESAHA.121.319721
Bartoli-Leonard F, Zimmer J, Aikawa E
Innate and adaptative immunity: The understudied driving force of heart valve disease.
Cardiovasc Res. 2021;117(13):2506-2524 - PMID: 34432007 - PMCID: PMC8783388 - DOI: 10.1093/cvr/cvab273
Rogers MA, Aikawa E
Unbiased omics identifies mechanistic regulators of calcific aortic valve disease.
Eur Heart J. 2021;42(30):2948-2950 - PMID: 34179985 - PMCID: PMC8347449 - DOI: 10.1093/eurheartj/ehab381
Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
Circulation. 2021;143(25):2454-2470 - PMID: 33821665 - PMCID: PMC8212880 - DOI: 10.1161/CIRCULATIONAHA.119.043724
Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.
Proc Natl Acad Sci U S A. 2021;118(14):ePub - PMID: 33795519 - PMCID: PMC8040669 - DOI: 10.1073/pnas.1811725118
Blaser MC, Kraler S, Lüscher TF, Aikawa E
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.
Circ Res. 2021;128(9):1371-1397 - PMID: 33914608 - PMCID: PMC8095729 - DOI: 10.1161/CIRCRESAHA.120.317979
Bartoli-Leonard F, Aikawa E
Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease.
Circ Res. 2021;128(9):1317-1319 - PMID: 33914606 - PMCID: PMC8095786 - DOI: 10.1161/CIRCRESAHA.121.319149
de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E
Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases.
Biomolecules. 2021;11(3):ePub - PMID: 33808038 - PMCID: PMC8001426 - DOI: 10.3390/biom11030388
Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V
Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.
Sci Adv. 2021;7(6):ePub - PMID: 33547080 - PMCID: PMC7864581 - DOI: 10.1126/sciadv.abe3706
Passos LSA, Nunes MCP, Aikawa E
Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.
Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716
Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Cardiovasc Res. 2021;117(11):2340-2353 - PMID: 33523181 - PMCID: PMC8479802 - DOI: 10.1093/cvr/cvab034
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E
ApoC-III is a novel inducer of calcification in human aortic valves.
J Biol Chem. 2020;296:100193 - PMID: 33334888 - PMCID: PMC7948477 - DOI: 10.1074/jbc.RA120.015700
Iqbal F, Lupieri A, Aikawa M, Aikawa E
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
Arterioscler Thromb Vasc Biol. 2020;41(2):585-600 - PMID: 33327741 - PMCID: PMC8105278 - DOI: 10.1161/ATVBAHA.120.314776
Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.
Arterioscler Thromb Vasc Biol. 2020;41(2):755-768 - PMID: 33356393 - PMCID: PMC8105275 - DOI: 10.1161/ATVBAHA.120.315007
Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.
JACC Basic Transl Sci. 2020;5(12):1187-1206 - PMID: 33426376 - PMCID: PMC7775962 - DOI: 10.1016/j.jacbts.2020.09.011
Atkins SK, Singh SA, Aikawa E
Calcific Aortic Valve Disease "Omics" Is Timely, But Are We Looking Too Late?
JACC Basic Transl Sci. 2020;5(12):1178-1180 - PMID: 33427821 - PMCID: PMC7775952 - DOI: 10.1016/j.jacbts.2020.11.001
Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E
Raising awareness for rheumatic mitral valve disease.
Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26
Bartoli-Leonard F, Aikawa E
Heart Valve Disease: Challenges and New Opportunities.
Front Cardiovasc Med. 2020;7:602271 - PMID: 33195488 - PMCID: PMC7642276 - DOI: 10.3389/fcvm.2020.602271
Aikawa E, Blaser MC
2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders.
Arterioscler Thromb Vasc Biol. 2020;41(1):117-127 - PMID: 33115271 - PMCID: PMC7832175 - DOI: 10.1161/ATVBAHA.120.314704
Rogers MA, Aikawa E
An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease.
JACC Basic Transl Sci. 2020;5(9):898-900 - PMID: 33016951 - PMCID: PMC7524779 - DOI: 10.1016/j.jacbts.2020.04.016
Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
Sci Adv. 2020;6(38):ePub - PMID: 32938681 - PMCID: PMC7494353 - DOI: 10.1126/sciadv.abb1244
Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.
JACC Cardiovasc Imaging. 2020;13(12):2513-2526 - PMID: 32950446 - PMCID: PMC7861508 - DOI: 10.1016/j.jcmg.2020.07.020
Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR
Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis.
Atherosclerosis. 2020;307:16-20 - PMID: 32702536 - PMCID: PMC7583087 - DOI: 10.1016/j.atherosclerosis.2020.06.019
Bartoli-Leonard F, Saddic L, Aikawa E
Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system.
Eur Heart J. 2020;41(26):2453-2455 - PMID: 32585692 - PMCID: PMC7340353 - DOI: 10.1093/eurheartj/ehaa444
Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E
S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.
Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087
Passos LSA, Lupieri A, Becker-Greene D, Aikawa E
Innate and adaptive immunity in cardiovascular calcification.
Atherosclerosis. 2020;306:59-67 - PMID: 32222287 - PMCID: PMC7483874 - DOI: 10.1016/j.atherosclerosis.2020.02.016
Rogers MA, Aikawa E
Complex association of lipoprotein(a) with aortic stenosis.
Heart. 2020;106(10):711-712 - PMID: 32086294 - DOI: 10.1136/heartjnl-2019-316498
Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J
Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.
J Am Coll Cardiol. 2020;75(4):395-405 - PMID: 32000951 - PMCID: PMC7946170 - DOI: 10.1016/j.jacc.2019.11.039
Rogers MA, Aikawa E
MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk.
Arterioscler Thromb Vasc Biol. 2019;39(12):2448-2450 - PMID: 31770027 - PMCID: PMC6980729 - DOI: 10.1161/ATVBAHA.119.313533
Atkins SK, Aikawa E
Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms.
Heart. 2019;105(21):1610-1611 - PMID: 31296591 - PMCID: PMC6855786 - DOI: 10.1136/heartjnl-2019-315236
Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR
Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis.
J Am Coll Cardiol. 2019;73(17):2150-2162 - PMID: 31047003 - PMCID: PMC6494952 - DOI: 10.1016/j.jacc.2019.01.070
Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E
Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification.
Front Cardiovasc Med. 2019;6:49 - PMID: 31041314 - PMCID: PMC6476921 - DOI: 10.3389/fcvm.2019.00049
Phillippi JA, Aikawa E, Hutcheson J
Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.
Front Cardiovasc Med. 2019;6:13 - PMID: 30873414 - PMCID: PMC6401650 - DOI: 10.3389/fcvm.2019.00013
Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.
Front Cardiovasc Med. 2019;6:8 - PMID: 30838213 - PMCID: PMC6382669 - DOI: 10.3389/fcvm.2019.00008
Blaser MC, Aikawa E
Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.
Circ Res. 2019;124(4):467-469 - PMID: 30763209 - PMCID: PMC6383776 - DOI: 10.1161/CIRCRESAHA.119.314596
Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E
18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.
Circ Cardiovasc Imaging. 2019;12(1):e007835 - PMID: 30642216 - PMCID: PMC6338081 - DOI: 10.1161/CIRCIMAGING.118.007835
Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH
Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.
J Am Coll Cardiol. 2019;73(2):190-209 - PMID: 30654892 - PMCID: PMC6865825 - DOI: 10.1016/j.jacc.2018.09.089
Blaser MC, Aikawa E
Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism.
Front Cardiovasc Med. 2018;5:187 - PMID: 30622949 - PMCID: PMC6308298 - DOI: 10.3389/fcvm.2018.00187
Rogers MA, Aikawa E
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.
Nat Rev Cardiol. 2018;16(5):261-274 - PMID: 30531869 - DOI: 10.1038/s41569-018-0123-8
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
J Extracell Vesicles. 2018;7(1):1535750 - PMID: 30637094 - PMCID: PMC6322352 - DOI: 10.1080/20013078.2018.1535750
Koenen RR, Aikawa E
Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases.
Front Cardiovasc Med. 2018;5:133 - PMID: 30283791 - PMCID: PMC6157324 - DOI: 10.3389/fcvm.2018.00133
Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabasi AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M
Uremic Toxin Indoxyl Sulfate Promotes Pro-Inflammatory Macrophage Activation via the Interplay of OATB2B1 and Dll4-Notch Signaling: Potential Mechanism for Accelerated Atherogenesis in Chronic Kidney Disease.
Circulation. 2018;139(1):78-96 - PMID: 30586693 - PMCID: PMC6311723 - DOI: 10.1161/CIRCULATIONAHA.118.034588
Dekker S, van Geemen D, van den Bogaerdt AJ, Driessen-Mol A, Aikawa E, Smits AIPM
Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves.
Front Cardiovasc Med. 2018;5:105 - PMID: 30159315 - PMCID: PMC6104173 - DOI: 10.3389/fcvm.2018.00105
Sen DG, Halu A, Razzaque M, Gorham JM, Hartnett J, Seidman JG, Aikawa E, Seidman CE
The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development.
Ann Thorac Surg. 2018;106(6):1834-1840 - PMID: 30071238 - DOI: 10.1016/j.athoracsur.2018.06.034
Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E
Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.
Sci Rep. 2018;8(1):9006 - PMID: 29899496 - PMCID: PMC5998044 - DOI: 10.1038/s41598-018-27416-y
Lei Y, Lei L, Wang Y, Singh SA, Aikawa E
TEMPORARY REMOVAL: Catalytically inactive phosphatase MTMR12 is a novel regulator of osteoclast function through F-actin ring formation.
Biochim Biophys Acta. 2018;:ePub - PMID: 29902551 - DOI: 10.1016/j.bbadis.2018.06.008
van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E
Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics.
Nanomaterials (Basel). 2018;8(5):ePub - PMID: 29751516 - PMCID: PMC5977310 - DOI: 10.3390/nano8050296
Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA
Mitral Valve Adaptation: Can We Win the Race?
Circ Cardiovasc Imaging. 2018;11(4):e007642 - PMID: 29626080 - PMCID: PMC5890943 - DOI: 10.1161/CIRCIMAGING.118.007642
Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E
Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.
Circulation. 2018;138(4):377-393 - PMID: 29588317 - PMCID: PMC6160370 - DOI: 10.1161/CIRCULATIONAHA.117.032291
Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM
Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction.
Ann Thorac Surg. 2018;105(6):1809-1818 - PMID: 29510094 - PMCID: PMC6292668 - DOI: 10.1016/j.athoracsur.2018.01.076
Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM
Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.
Int J Mol Sci. 2018;19(3):ePub - PMID: 29495441 - PMCID: PMC5877524 - DOI: 10.3390/ijms19030663
Hutcheson JD, Aikawa E
Extracellular vesicles in cardiovascular homeostasis and disease.
Curr Opin Cardiol. 2018;33(3):290-297 - PMID: 29465447 - PMCID: PMC5895489 - DOI: 10.1097/HCO.0000000000000510
Itoh S, Mizuno K, Aikawa M, Aikawa E
Dimerization of sortilin regulates its trafficking to extracellular vesicles.
J Biol Chem. 2018;293(12):4532-4544 - PMID: 29382723 - PMCID: PMC5868269 - DOI: 10.1074/jbc.RA117.000732
Sena BF, Figueiredo JL, Aikawa E
Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease.
Front Cardiovasc Med. 2018;4:88 - PMID: 29379789 - PMCID: PMC5770806 - DOI: 10.3389/fcvm.2017.00088
Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK
Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation.
JACC Cardiovasc Imaging. 2017;12(4):665-677 - PMID: 29248661 - PMCID: PMC5993562 - DOI: 10.1016/j.jcmg.2017.09.013
Goettsch C, Kjolby M, Aikawa E
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Arterioscler Thromb Vasc Biol. 2017;38(1):19-25 - PMID: 29191923 - PMCID: PMC5746432 - DOI: 10.1161/ATVBAHA.117.310292
Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH
Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.
Eur Heart J. 2017;39(28):2618-2624 - PMID: 29136138 - PMCID: PMC6055545 - DOI: 10.1093/eurheartj/ehx653
Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA
Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling.
Circ Cardiovasc Imaging. 2017;10(11):ePub - PMID: 29042413 - PMCID: PMC5683411 - DOI: 10.1161/CIRCIMAGING.117.006512
Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ
New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
Eur Heart J. 2017;39(15):1269-1277 - PMID: 29020406 - PMCID: PMC5905589 - DOI: 10.1093/eurheartj/ehx505
Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA,
Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.
J Am Coll Cardiol. 2017;70(10):1232-1244 - PMID: 28859786 - PMCID: PMC5679094 - DOI: 10.1016/j.jacc.2017.07.734
Rogers M, Maldonado-Martinez N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.
Circ Res. 2017;121(3):220-233 - PMID: 28607103 - PMCID: PMC5546003 - DOI: 10.1161/CIRCRESAHA.116.310293
Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J
Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.
Adv Funct Mater. 2017;27(27):ePub - PMID: 32863817 - PMCID: PMC7450820 - DOI: 10.1002/adfm.201606614
Rogers MA, Aikawa M, Aikawa E
Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues.
Circ Res. 2017;121(1):5-7 - PMID: 28642321 - PMCID: PMC5507366 - DOI: 10.1161/CIRCRESAHA.117.311219
Aikawa E, Libby P
A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis.
Circulation. 2017;135(20):1951-1955 - PMID: 28507250 - PMCID: PMC5479353 - DOI: 10.1161/CIRCULATIONAHA.117.027776
Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce K, Libby P
Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice - Implications for Superficial Erosion.
Circ Res. 2017;121(1):31-42 - PMID: 28428204 - PMCID: PMC5488735 - DOI: 10.1161/CIRCRESAHA.117.310694
Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E
Interferon-? Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.
Am J Pathol. 2017;187(6):1413-1425 - PMID: 28431214 - PMCID: PMC5455058 - DOI: 10.1016/j.ajpath.2017.02.012
Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men.
Arterioscler Thromb Vasc Biol. 2017;37(5):1005-1011 - PMID: 28279970 - PMCID: PMC5407935 - DOI: 10.1161/ATVBAHA.116.308932
van der Ven CF, Wu PJ, Tibbitt MW, van Mil A, Sluijter JP, Langer R, Aikawa E
In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease.
Clin Sci (Lond). 2017;131(3):181-195 - PMID: 28057890 - PMCID: PMC5459552 - DOI: 10.1042/CS20160378
Hutcheson JD, Blaser MC, Aikawa E
Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field.
Circ Res. 2017;120(2):270-273 - PMID: 28104767 - PMCID: PMC5260841 - DOI: 10.1161/CIRCRESAHA.116.310060
Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E
Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development.
Front Cardiovasc Med. 2016;3:44 - PMID: 27867942 - PMCID: PMC5095138 - DOI: 10.3389/fcvm.2016.00044
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Nat Commun. 2016;7:12849 - PMID: 27796300 - PMCID: PMC5095532 - DOI: 10.1038/ncomms12849
Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko P, Guerrero J, Dal-Bianco J, Beaudoin J, Garcia M, Sullivan S, Seybolt M, Morris B, Keegan J, Irvin W, Aikawa E, Levine R
CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction.
Circ Res. 2016;119(11):1215-1225 - PMID: 27750208 - PMCID: PMC5215059 - DOI: 10.1161/CIRCRESAHA.116.309598
Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E
Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency.
Semin Thorac Cardiovasc Surg. 2016;28(4):757-767 - PMID: 28417861 - DOI: 10.1053/j.semtcvs.2016.08.015
Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
Cell Stem Cell. 2016;19(5):628-642 - PMID: 27618218 - PMCID: PMC5097006 - DOI: 10.1016/j.stem.2016.08.001
Singh SA, Aikawa E, Aikawa M
Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research.
Circ J. 2016;80(8):1674-83 - PMID: 27430298 - DOI: 10.1253/circj.CJ-16-0499
Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA
Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.
Circ Res. 2016;119(2):330-40 - PMID: 27390335 - PMCID: PMC4939871 - DOI: 10.1161/CIRCRESAHA.116.307971
Mosch J, Gleissner CA, Body S, Aikawa E
Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.
Histol Histopathol. 2016;32(3):293-306 - PMID: 27353274 - PMCID: PMC5199639 - DOI: 10.14670/HH-11-797
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Atherosclerosis. 2016;251:109-118 - PMID: 27318830 - PMCID: PMC4983246 - DOI: 10.1016/j.atherosclerosis.2016.06.011
Aikawa E
Extracellular vesicles in cardiovascular disease: focus on vascular calcification.
J Physiol. 2016;594(11):2877-80 - PMID: 27246548 - PMCID: PMC4887668 - DOI: 10.1113/JP272112
O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.
J Vis Exp. 2016;(111):ePub - PMID: 27284788 - PMCID: PMC4927747 - DOI: 10.3791/54017
Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD
Zooming in on the genesis of atherosclerotic plaque microcalcifications.
J Physiol. 2016;594(11):2915-27 - PMID: 27040360 - PMCID: PMC4887667 - DOI: 10.1113/JP271339
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
J Mol Cell Cardiol. 2016;94:13-20 - PMID: 26996755 - PMCID: PMC4906202 - DOI: 10.1016/j.yjmcc.2016.03.004
Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA
3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.
Eur Heart J Cardiovasc Imaging. 2016;17(5):510-1 - PMID: 26976355 - PMCID: PMC4829123 - DOI: 10.1093/ehjci/jew029
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
J Clin Invest. 2016;126(4):1323-36 - PMID: 26950419 - PMCID: PMC4811143 - DOI: 10.1172/JCI80851
Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E
Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.
J Physiol. 2016;594(11):2895-903 - PMID: 26824781 - PMCID: PMC4887674 - DOI: 10.1113/JP271338
Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E
Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-? Signaling.
Arterioscler Thromb Vasc Biol. 2016;36(3):525-33 - PMID: 26800565 - PMCID: PMC4767541 - DOI: 10.1161/ATVBAHA.115.307009
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.
Nat Mater. 2016;15(3):335-43 - PMID: 26752654 - PMCID: PMC4767675 - DOI: 10.1038/nmat4519
Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA,
Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
J Am Coll Cardiol. 2016;67(3):275-87 - PMID: 26796392 - PMCID: PMC5099077 - DOI: 10.1016/j.jacc.2015.10.092
Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,
Mitral valve disease-morphology and mechanisms.
Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623 - DOI: 10.1038/nrcardio.2015.161
Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.
PLoS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429 - DOI: 10.1371/journal.pone.0138047
Hutcheson JD, Goettsch C, Rogers MA, Aikawa E
Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach.
Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815 - DOI: 10.1016/j.semcdb.2015.09.004
Rogers MA, Aikawa E
A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.
Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561 - DOI: 10.1161/CIRCULATIONAHA.115.018139
Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E
Valvular interstitial cells suppress calcification of valvular endothelial cells.
Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848 - DOI: 10.1016/j.atherosclerosis.2015.07.008
Aikawa E, Fujita R, Kikuchi Y, Kaneda Y, Tamai K
Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFR?(+) mesenchymal cells from bone marrow.
Sci Rep. 2015;5:11008 - PMID: 26046579 - PMCID: PMC4457135 - DOI: 10.1038/srep11008
Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E
N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification
J. Cardiovasc. Dev. Dis. 2015;2(2):31-47 - PMID: 29371511 - PMCID: PMC5753093 - DOI: 10.3390/jcdd2020031
Ruiz JL, Hutcheson JD, Aikawa E
Cardiovascular calcification: current controversies and novel concepts.
Cardiovasc Pathol. 2015;24(4):207-12 - PMID: 25797772 - DOI: 10.1016/j.carpath.2015.03.002
Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E
Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.
Am J Pathol. 2015;185(4):1156-66 - PMID: 25680278 - PMCID: PMC4380840 - DOI: 10.1016/j.ajpath.2014.11.026
Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E
Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.
J Extracell Vesicles. 2014;3:25129 - PMID: 25491249 - PMCID: PMC4261240 - DOI: 10.3402/jev.v3.25129
Fujita R, Tamai K, Aikawa E, Nimura K, Ishino S, Kikuchi Y, Kaneda Y
Endogenous Mesenchymal Stromal Cells in Bone Marrow are Required to Preserve Muscle Function in Mdx Mice.
Stem Cells. 2014;33(3):962-75 - PMID: 25408548 - DOI: 10.1002/stem.1900
Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, St?pie? E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS
EVpedia: a community web portal for extracellular vesicles research.
Bioinformatics. 2014;31(6):933-9 - PMID: 25388151 - PMCID: PMC4375401 - DOI: 10.1093/bioinformatics/btu741
Hutcheson JD, Maldonado N, Aikawa E
Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.
Curr Opin Lipidol. 2014;25(5):327-32 - PMID: 25188916 - PMCID: PMC4166045 - DOI: 10.1097/MOL.0000000000000105
Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E
Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease.
Arterioscler Thromb Vasc Biol. 2014;34(11):2387-93 - PMID: 25189570 - PMCID: PMC4199903 - DOI: 10.1161/ATVBAHA.114.302523
Goettsch C, Iwata H, Aikawa E
Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.
Arterioscler Thromb Vasc Biol. 2014;34(7):1333-5 - PMID: 24951650 - PMCID: PMC4094346 - DOI: 10.1161/ATVBAHA.114.303637
Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A
Directing Valvular Interstitial Cell Myofibroblast-Like Differentiation in a Hybrid Hydrogel Platform.
Adv Healthc Mater. 2014;4(1):121-30 - PMID: 24958085 - PMCID: PMC4276556 - DOI: 10.1002/adhm.201400029
Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E
A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.
PLoS One. 2014;9(3):e89627 - PMID: 24595280 - PMCID: PMC3940696 - DOI: 10.1371/journal.pone.0089627
Rogers MA, Aikawa E
Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation.
Circ Res. 2014;114(7):1074-6 - PMID: 24677232 - PMCID: PMC3989539 - DOI: 10.1161/CIRCRESAHA.114.303684
Hutcheson JD, Aikawa E, Merryman WD
Potential drug targets for calcific aortic valve disease.
Nat Rev Cardiol. 2014;11(4):218-31 - PMID: 24445487 - PMCID: PMC4263317 - DOI: 10.1038/nrcardio.2014.1
Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E
Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis.
Arterioscler Thromb Vasc Biol. 2013;34(3):626-34 - PMID: 24357058 - PMCID: PMC3959796 - DOI: 10.1161/ATVBAHA.113.302576
Aikawa E, Gardiner C, Hutcheson JD, Ochiya T, Osteikoetxea X, Pegtel M, Piper M, Quesenberry P, Schiffelers RM, Szabó TG, Buzas EI
International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013).
J Extracell Vesicles. 2013;2:23070 - PMID: 26082318 - PMCID: PMC3854124 - DOI: 10.3402/jev.v2i0.23070
Rogers M, Goettsch C, Aikawa E
Medial and intimal calcification in chronic kidney disease: stressing the contributions.
J Am Heart Assoc. 2013;2(5):e000481 - PMID: 24060959 - PMCID: PMC3835265 - DOI: 10.1161/JAHA.113.000481
New SE, Aikawa E
Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification.
Arterioscler Thromb Vasc Biol. 2013;33(8):1753-8 - PMID: 23766262 - PMCID: PMC3788633 - DOI: 10.1161/ATVBAHA.112.300128
Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, Weinbaum S
Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries.
Proc Natl Acad Sci U S A. 2013;110(26):10741-6 - PMID: 23733926 - PMCID: PMC3696743 - DOI: 10.1073/pnas.1308814110
Wang JG, Aikawa E, Aikawa M
Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis.
J Am Coll Cardiol. 2013;62(16):1442-5 - PMID: 23707315 - DOI: 10.1016/j.jacc.2013.04.054
Votteler M, Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K
Elastogenesis at the onset of human cardiac valve development.
Development. 2013;140(11):2345-53 - PMID: 23637335 - PMCID: PMC3912871 - DOI: 10.1242/dev.093500
New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E
Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.
Circ Res. 2013;113(1):72-7 - PMID: 23616621 - PMCID: PMC3703850 - DOI: 10.1161/CIRCRESAHA.113.301036
Abe J, Manabe I, Aikawa M, Aikawa E
Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation.
Int J Inflam. 2013;2013:953463 - PMID: 23555068 - PMCID: PMC3608100 - DOI: 10.1155/2013/953463
Goettsch C, Hutcheson JD, Aikawa E
MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.
Circ Res. 2013;112(7):1073-84 - PMID: 23538277 - PMCID: PMC3668680 - DOI: 10.1161/CIRCRESAHA.113.300937
Hjortnaes J, New SE, Aikawa E
Visualizing novel concepts of cardiovascular calcification.
Trends Cardiovasc Med. 2013;23(3):71-9 - PMID: 23290463 - PMCID: PMC3626075 - DOI: 10.1016/j.tcm.2012.09.003
Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation.
PLoS Biol. 2012;10(12):e1001450 - PMID: 23271954 - PMCID: PMC3525526 - DOI: 10.1371/journal.pbio.1001450
Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.
Eur Heart J. 2012;34(8):615-24 - PMID: 22927557 - PMCID: PMC3578265 - DOI: 10.1093/eurheartj/ehs271
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109
Aikawa M, Manabe I, Chester A, Aikawa E
Cardiovascular inflammation.
Int J Inflam. 2012;2012:904608 - PMID: 22518345 - PMCID: PMC3317089 - DOI: 10.1155/2012/904608
Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis.
Arterioscler Thromb Vasc Biol. 2012;32(3):613-22 - PMID: 22223731 - PMCID: PMC3679546 - DOI: 10.1161/ATVBAHA.111.242594
Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK
Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.
Proc Natl Acad Sci U S A. 2011;108(50):19943-8 - PMID: 22123981 - PMCID: PMC3250145 - DOI: 10.1073/pnas.1106954108
Aikawa E, Otto CM
Look more closely at the valve: imaging calcific aortic valve disease.
Circulation. 2011;125(1):9-11 - PMID: 22090164 - DOI: 10.1161/CIRCULATIONAHA.111.073452
Su HS, Nahrendorf M, Panizzi P, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW
Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.
Radiology. 2011;262(1):181-90 - PMID: 22084204 - PMCID: PMC3244672 - DOI: 10.1148/radiol.11110040
Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P
Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis.
Arterioscler Thromb Vasc Biol. 2011;31(11):2464-72 - PMID: 21903941 - PMCID: PMC3200308 - DOI: 10.1161/ATVBAHA.111.231563
Goettsch C, Rauner M, Sinningen K, Helas S, Al-Fakhri N, Nemeth K, Hamann C, Kopprasch S, Aikawa E, Bornstein SR, Schoppet M, Hofbauer LC
The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells.
Endocrinology. 2011;152(12):4915-26 - PMID: 22009730 - DOI: 10.1210/en.2011-1282
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM
Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.
Circulation. 2011;124(16):1783-91 - PMID: 22007101 - PMCID: PMC3306614 - DOI: 10.1161/CIRCULATIONAHA.110.006767
Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.
Nat Med. 2011;17(9):1142-6 - PMID: 21857652 - PMCID: PMC3169740 - DOI: 10.1038/nm.2423
Bischoff J, Aikawa E
Progenitor cells confer plasticity to cardiac valve endothelium.
J Cardiovasc Transl Res. 2011;4(6):710-9 - PMID: 21789724 - DOI: 10.1007/s12265-011-9312-0
New SE, Aikawa E
Cardiovascular calcification: an inflammatory disease.
Circ J. 2011;75(6):1305-13 - PMID: 21566338 - DOI: 10.1253/circj.cj-11-0395
Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA
Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.
Sci Transl Med. 2011;3(84):84ra45 - PMID: 21613624 - PMCID: PMC3112179 - DOI: 10.1126/scitranslmed.3001577
New SE, Aikawa E
Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification.
Circ Res. 2011;108(11):1381-91 - PMID: 21617135 - PMCID: PMC3139950 - DOI: 10.1161/CIRCRESAHA.110.234146
Brokopp CE, Schoenauer R, Richards P, Bauer S, Lohmann C, Emmert MY, Weber B, Winnik S, Aikawa E, Graves K, Genoni M, Vogt P, Lüscher TF, Renner C, Hoerstrup SP, Matter CM
Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata.
Eur Heart J. 2011;32(21):2713-22 - PMID: 21292680 - PMCID: PMC3205479 - DOI: 10.1093/eurheartj/ehq519
Wylie-Sears J, Aikawa E, Levine RA, Yang JH, Bischoff J
Mitral valve endothelial cells with osteogenic differentiation potential.
Arterioscler Thromb Vasc Biol. 2010;31(3):598-607 - PMID: 21164078 - PMCID: PMC3210435 - DOI: 10.1161/ATVBAHA.110.216184
Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA
Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.
Arterioscler Thromb Vasc Biol. 2010;30(10):1933-9 - PMID: 20689078 - PMCID: PMC3030475 - DOI: 10.1161/ATVBAHA.110.206342
Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer JE, Aikawa E
Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study.
Tissue Eng Part C Methods. 2010;16(4):597-607 - PMID: 19751103 - PMCID: PMC7875113 - DOI: 10.1089/ten.TEC.2009.0466
Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.
Eur Heart J. 2010;31(16):1975-84 - PMID: 20601388 - PMCID: PMC2921509 - DOI: 10.1093/eurheartj/ehq237
Norris RA, Moreno-Rodriguez R, Wessels A, Merot J, Bruneval P, Chester AH, Yacoub MH, Hagège A, Slaugenhaupt SA, Aikawa E, Schott JJ, Lardeux A, Harris BS, Williams LK, Richards A, Levine RA, Markwald RR
Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis.
Dev Dyn. 2010;239(7):2118-27 - PMID: 20549728 - PMCID: PMC2909582 - DOI: 10.1002/dvdy.22346
Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089
Gottlieb D, Kunal T, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC, Melero-Martin JM, Sacks MS, Mayer JE
In vivo monitoring of function of autologous engineered pulmonary valve.
J Thorac Cardiovasc Surg. 2010;139(3):723-31 - PMID: 20176213 - DOI: 10.1016/j.jtcvs.2009.11.006
Sales VL, Mettler BA, Engelmayr GC, Aikawa E, Bischoff J, Martin DP, Exarhopoulos A, Moses MA, Schoen FJ, Sacks MS, Mayer JE
Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves.
Tissue Eng Part A. 2010;16(1):257-67 - PMID: 19698056 - PMCID: PMC2811057 - DOI: 10.1089/ten.TEA.2009.0424
Ramaswamy S, Gottlieb D, Engelmayr GC, Aikawa E, Schmidt DE, Gaitan-Leon DM, Sales VL, Mayer JE, Sacks MS
The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells.
Biomaterials. 2009;31(6):1114-25 - PMID: 19944458 - PMCID: PMC2813971 - DOI: 10.1016/j.biomaterials.2009.10.019
Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA
Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.
J Am Chem Soc. 2009;131(43):15739-44 - PMID: 19817443 - PMCID: PMC2773134 - DOI: 10.1021/ja903922u
Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.
JACC Cardiovasc Imaging. 2009;2(10):1213-22 - PMID: 19833312 - PMCID: PMC2773129 - DOI: 10.1016/j.jcmg.2009.04.016
Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L
Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.
Circ Cardiovasc Imaging. 2009;2(6):460-7 - PMID: 19920044 - PMCID: PMC2780438 - DOI: 10.1161/CIRCIMAGING.109.859678
Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A
Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.
Circ Cardiovasc Imaging. 2009;2(6):468-75 - PMID: 19920045 - PMCID: PMC2782621 - DOI: 10.1161/CIRCIMAGING.109.863779
Deguchi JO, Yamazaki H, Aikawa E, Aikawa M
Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages.
Arterioscler Thromb Vasc Biol. 2009;29(10):1664-70 - PMID: 19644051 - DOI: 10.1161/ATVBAHA.109.194043
Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R
Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.
Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251 - DOI: 10.1161/ATVBAHA.109.193086
Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA, Carpentier A
Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation.
Circulation. 2009;120(4):334-42 - PMID: 19597052 - PMCID: PMC2752046 - DOI: 10.1161/CIRCULATIONAHA.108.846782
Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ
Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
Science. 2009;325(5940):612-6 - PMID: 19644120 - PMCID: PMC2803111 - DOI: 10.1126/science.1175202
Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L
The antiproliferative cytostatic effects of a self-activating viridin prodrug.
Mol Cancer Ther. 2009;8(6):1666-75 - PMID: 19509266 - PMCID: PMC2740925 - DOI: 10.1158/1535-7163.MCT-08-1012
Christen T, Nahrendorf M, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P
Molecular imaging of innate immune cell function in transplant rejection.
Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889 - DOI: 10.1161/CIRCULATIONAHA.108.796888
Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.
Circulation. 2009;119(13):1785-94 - PMID: 19307473 - PMCID: PMC2717745 - DOI: 10.1161/CIRCULATIONAHA.108.827972
Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ, Wedeen VJ
Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium.
Circ Cardiovasc Imaging. 2009;2(3):206-12 - PMID: 19808594 - PMCID: PMC2760045 - DOI: 10.1161/CIRCIMAGING.108.815050
Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.
Integr Biol (Camb). 2009;1(4):311-7 - PMID: 20023731 - PMCID: PMC2748356 - DOI: 10.1039/b821775k
Deguchi JO, Huang H, Libby P, Aikawa E, Whittaker P, Sylvan J, Lee RT, Aikawa M
Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II.
Lab Invest. 2009;89(3):315-26 - PMID: 19153555 - PMCID: PMC2932654 - DOI: 10.1038/labinvest.2008.167
McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Neuroimage. 2008;45(2):360-9 - PMID: 19154791 - PMCID: PMC2707831 - DOI: 10.1016/j.neuroimage.2008.12.022
Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
Proc Natl Acad Sci U S A. 2008;105(49):19126-31 - PMID: 19015534 - PMCID: PMC2614726 - DOI: 10.1073/pnas.0804798105
Breckwoldt MO, Chen JW, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz MA, Weissleder R
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.
Proc Natl Acad Sci U S A. 2008;105(47):18584-9 - PMID: 19011099 - PMCID: PMC2587593 - DOI: 10.1073/pnas.0803945105
Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis.
Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441 - DOI: 10.1161/CIRCULATIONAHA.108.785881
Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L
Simplified syntheses of complex multifunctional nanomaterials.
Chem Commun (Camb). 2008;(39):4792-4 - PMID: 18830495 - PMCID: PMC2692914 - DOI: 10.1039/b809537j
Rusanescu G, Weissleder R, Aikawa E
Notch signaling in cardiovascular disease and calcification.
Curr Cardiol Rev. 2008;4(3):148-56 - PMID: 19936191 - PMCID: PMC2780816 - DOI: 10.2174/157340308785160552
Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R
Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.
Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051 - DOI: 10.1161/CIRCULATIONAHA.107.756510
Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne SW, Blankesteijn WM, Sosnovik DE, Jaffer FA, Tung CH, Weissleder R
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.
Eur Heart J. 2008;29(4):445-54 - PMID: 18276618 - DOI: 10.1093/eurheartj/ehm558
Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain. 2008;131(Pt 4):1123-33 - PMID: 18234693 - PMCID: PMC4044727 - DOI: 10.1093/brain/awn004
Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.
Circulation. 2007;117(3):379-87 - PMID: 18158358 - PMCID: PMC2663426 - DOI: 10.1161/CIRCULATIONAHA.107.741181
Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50 - PMID: 18040026 - DOI: 10.1161/CIRCULATIONAHA.107.732867
Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517 - DOI: 10.1084/jem.20070885
Mendelson K, Aikawa E, Mettler BA, Sales V, Martin D, Mayer JE, Schoen FJ
Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep.
Cardiovasc Pathol. 2007;16(5):277-82 - PMID: 17868878 - DOI: 10.1016/j.carpath.2007.03.008
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor.
Circulation. 2007;115(17):2292-8 - PMID: 17420353 - DOI: 10.1161/CIRCULATIONAHA.106.660340
Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.
Circ Res. 2007;100(8):1218-25 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31
Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V
Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo.
Circulation. 2007;115(11):1384-91 - PMID: 17339546 - DOI: 10.1161/CIRCULATIONAHA.106.663351
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.
Circulation. 2007;115(3):377-86 - PMID: 17224478 - DOI: 10.1161/CIRCULATIONAHA.106.654913
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.
J Clin Invest. 2007;117(1):195-205 - PMID: 17200719 - PMCID: PMC1716211 - DOI: 10.1172/JCI29950
Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.
Circulation. 2006;114(14):1504-11 - PMID: 17000904 - DOI: 10.1161/CIRCULATIONAHA.106.646380
Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.
Circ Res. 2006;99(8):861-9 - PMID: 16973908 - PMCID: PMC2810464 - DOI: 10.1161/01.RES.0000245188.41002.2c
Jaffer FA, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R
Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials.
Mol Imaging. 2006;5(2):85-92 - PMID: 16954022
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
Proc Natl Acad Sci U S A. 2006;103(27):10340-10345 - PMID: 16801531 - PMCID: PMC1502459 - DOI: 10.1073/pnas.0604260103
Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P
Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.
Circulation. 2006;114(1):55-62 - PMID: 16801460 - DOI: 10.1161/CIRCULATIONAHA.106.619056
Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
Circulation. 2006;113(19):2301-12 - PMID: 16682613 - DOI: 10.1161/CIRCULATIONAHA.105.605121
Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
J Biomed Opt. 2006;11(2):021009 - PMID: 16674184 - DOI: 10.1117/1.2186337
Aikawa E, Whittaker P, Farber M, Mendelson K, Padera RF, Aikawa M, Schoen FJ
Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.
Circulation. 2006;113(10):1344-52 - PMID: 16534030 - DOI: 10.1161/CIRCULATIONAHA.105.591768
Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M
Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques.
Circulation. 2005;112(17):2708-15 - PMID: 16230484 - DOI: 10.1161/CIRCULATIONAHA.105.562041
Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
Circulation. 2005;112(15):2324-31 - PMID: 16203910 - DOI: 10.1161/CIRCULATIONAHA.105.538942
Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation. 2005;112(4):578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616
Sutherland FW, Perry TE, Yu Y, Sherwood MC, Rabkin E, Masuda Y, Garcia GA, McLellan DL, Engelmayr GC, Sacks MS, Schoen FJ, Mayer JE
From stem cells to viable autologous semilunar heart valve.
Circulation. 2005;111(21):2783-91 - PMID: 15927990 - DOI: 10.1161/CIRCULATIONAHA.104.498378
Engelmayr GC, Rabkin E, Sutherland FW, Schoen FJ, Mayer JE, Sacks MS
The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue.
Biomaterials. 2005;26(2):175-87 - PMID: 15207464 - DOI: 10.1016/j.biomaterials.2004.02.035
Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ
Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.
J Thorac Cardiovasc Surg. 2004;128(4):552-61 - PMID: 15457156 - DOI: 10.1016/j.jtcvs.2004.04.016
Fukumoto Y, Deguchi JO, Libby P, Rabkin-Aikawa E, Sakata Y, Chin MT, Hill CC, Lawler PR, Varo N, Schoen FJ, Krane SM, Aikawa M
Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques.
Circulation. 2004;110(14):1953-9 - PMID: 15451791 - DOI: 10.1161/01.CIR.0000143174.41810.10
Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ
Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.
J Heart Valve Dis. 2004;13(5):841-7 - PMID: 15473488
Wu X, Rabkin-Aikawa E, Guleserian KJ, Perry TE, Masuda Y, Sutherland FW, Schoen FJ, Mayer JE, Bischoff J
Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells.
Am J Physiol Heart Circ Physiol. 2004;287(2):H480-7 - PMID: 15277191 - DOI: 10.1152/ajpheart.01232.2003
Simoncini T, Rabkin E, Liao JK
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
Arterioscler Thromb Vasc Biol. 2003;23(2):198-203 - PMID: 12588759 - DOI: 10.1161/01.atv.0000053846.71621.93
Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J
NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.
J Biol Chem. 2002;278(3):1686-92 - PMID: 12427739 - PMCID: PMC2813494 - DOI: 10.1074/jbc.M210250200
Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P
Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma.
Circulation. 2002;106(11):1390-6 - PMID: 12221058 - DOI: 10.1161/01.cir.0000028465.52694.9b
Rabkin E, Hoerstrup SP, Aikawa M, Mayer JE, Schoen FJ
Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling.
J Heart Valve Dis. 2002;11(3):308-14; discussion 314 - PMID: 12056720
Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT
Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.
Circulation. 2002;105(6):753-8 - PMID: 11839633 - DOI: 10.1161/hc0602.103674
Rabkin E, Aikawa M, Stone JR, Fukumoto Y, Libby P, Schoen FJ
Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves.
Circulation. 2001;104(21):2525-32 - PMID: 11714645 - DOI: 10.1161/hc4601.099489
Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J
Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro.
Am J Pathol. 2001;159(4):1335-43 - PMID: 11583961 - PMCID: PMC1850524 - DOI: 10.1016/s0002-9440(10)62520-5
Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE
Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo.
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Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy.
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An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro.
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Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction.
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Dietary lipid lowering reduces tissue factor expression in rabbit atheroma.
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Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.
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Aikawa M, Rabkin E, Voglic SJ, Shing H, Nagai R, Schoen FJ, Libby P
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Circulation. 1998;97(24):2433-44 - PMID: 9641696 - DOI: 10.1161/01.cir.97.24.2433
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Acute rejection accelerates graft coronary disease in transplanted rabbit hearts.
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