Aikawa-Aikawa Laboratories

Passos, Livia

Research Fellow

857-928-9243

lsilvaaraujopassos@bwh.harvard.edu

Dr. Livia Passos obtained her PhD in Sciences in the Federal University of Minas Gerais, Brazil in 2017. During her academic career she investigated immmunoregulatory mechanisms in infectious and parasitic diseases. After her PhD, Dr. Passos joined the group of Dr. Elena Aikawa in November 2017 to study cellular and molecular mechanisms that underlie Rheumatic Heart Disease (RHD), a major proportion of all cardiovascular disease in children and young adults in low and middle income countries. She focuses on understanding the process of lesion development leading to mitral valve dysfunction in RHD.

Publications

Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E

Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.

Eur Heart J. 2023;44(10):885-898 - PMID: 36660854 - PMCID: PMC9991042 - DOI: 10.1093/eurheartj/ehac818

Katsuki S, Kumar Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, Vittorio Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M

Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.

Circ Res. 2022;131(11):873-889 - PMID: 36263780 - PMCID: PMC9973449 - DOI: 10.1161/CIRCRESAHA.121.320056

Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO, Aikawa E, Hung J, Nunes MCP

Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling.

Front Cardiovasc Med. 2022;9:862382 - PMID: 35360029 - PMCID: PMC8962951 - DOI: 10.3389/fcvm.2022.862382

Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E

Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8⁺ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease.

Circulation. 2022;145(7):531-548 - PMID: 35157519 - PMCID: PMC8869797 - DOI: 10.1161/CIRCULATIONAHA.121.057301

Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E

Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.

Front Cardiovasc Med. 2021;8:688396 - PMID: 34458332 - PMCID: PMC8387660 - DOI: 10.3389/fcvm.2021.688396

Passos LSA, Nunes MCP, Aikawa E

Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms.

Front Cardiovasc Med. 2021;7:612716 - PMID: 33537348 - PMCID: PMC7848031 - DOI: 10.3389/fcvm.2020.612716

Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E

Raising awareness for rheumatic mitral valve disease.

Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26

Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J

Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.

JACC Cardiovasc Imaging. 2020;13(12):2513-2526 - PMID: 32950446 - PMCID: PMC7861508 - DOI: 10.1016/j.jcmg.2020.07.020

Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E

S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.

Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087

Passos LSA, Lupieri A, Becker-Greene D, Aikawa E

Innate and adaptive immunity in cardiovascular calcification.

Atherosclerosis. 2020;306:59-67 - PMID: 32222287 - PMCID: PMC7483874 - DOI: 10.1016/j.atherosclerosis.2020.02.016

Magalhães LMD, Passos LSA, Chiari E, Galvão LMC, Koh CC, Rodrigues-Alves ML, Giunchetti RC, Gollob K, Dutra WO

Co-infection with distinct Trypanosoma cruzi strains induces an activated immune response in human monocytes.

Parasite Immunol. 2019;41(11):e12668 - PMID: 31494949 - PMCID: PMC6800597 - DOI: 10.1111/pim.12668

Guimarães Júnior MH, Ferrari TCA, Teixeira-Carvalho A, Moreira ML, de Souza Santos LJ, Costa-Silva MF, Coelho RMP, Pinto PHOM, Ris TH, Salles JT, Passos LSA, Nunes MCP

Cell-derived microvesicles in infective endocarditis: role in diagnosis and potential for risk stratification at hospital admission.

J Infect. 2019;79(2):101-107 - PMID: 31207323 - DOI: 10.1016/j.jinf.2019.06.005

Diamantino Soares AC, Araújo Passos LS, Sable C, Beaton A, Ribeiro VT, Gollob KJ, Dutra WO, Nunes MCP

Circulating cytokines predict severity of rheumatic heart disease.

Int J Cardiol. 2019;289:107-109 - PMID: 31079974 - DOI: 10.1016/j.ijcard.2019.04.063

Passos LSA, Magalhães LMD, Soares RP, Marques AF, Nunes MDCP, Gollob KJ, Dutra WO

Specific activation of CD4–CD8– double‐negative T cells by Trypanosoma cruzi‐derived glycolipids induces a proinflammatory profile associated with cardiomyopathy in Chagas patients.

Clin Exp Immunol. 2017;190(1):122-132 - PMID: 28543170 - PMCID: PMC5588767 - DOI: 10.1111/cei.12992

Passos LS, Gazzinelli-Guimarães PH, Oliveira Mendes TA, Guimarães AC, Silveira Lemos DD, Ricci ND, Gonçalves R, Bartholomeu DC, Fujiwara RT, Bueno LL

Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection.

BMC Infect Dis. 2017;17(1):253 - PMID: 28390393 - PMCID: PMC5385058 - DOI: 10.1186/s12879-017-2366-0

Passos LS, Villani FN, Magalhães LM, Gollob KJ, Antonelli LR, Nunes MC, Dutra WO

Blocking of CD1d Decreases Trypanosoma cruzi-Induced Activation of CD4-CD8- T Cells and Modulates the Inflammatory Response in Patients With Chagas Heart Disease.

J Infect Dis. 2016;214(6):935-44 - PMID: 27368347 - DOI: 10.1093/infdis/jiw266

Hojo-Souza NS, Pereira DB, Passos LS, Gazzinelli-Guimarães PH, Cardoso MS, Tada MS, Zanini GM, Bartholomeu DC, Fujiwara RT, Bueno LL

Phenotypic profiling of CD8(+) T cells during Plasmodium vivax blood-stage infection.

BMC Infect Dis. 2015;15:35 - PMID: 25636730 - PMCID: PMC4329216 - DOI: 10.1186/s12879-015-0762-x

Hojo-Souza NS, Pereira DB, Mendes TA, Passos LS, Gazzinelli-Guimarães AC, Gazzinelli-Guimarães PH, Tada MS, Zanini GM, Bartholomeu DC, Fujiwara RT, Bueno LL

CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways.

Malar J. 2015;14:5 - PMID: 25559491 - PMCID: PMC4326293 - DOI: 10.1186/1475-2875-14-5

Fiuza JA, Gannavaram S, Santiago Hda C, Selvapandiyan A, Souza DM, Passos LS, de Mendonça LZ, Lemos-Giunchetti Dda S, Ricci ND, Bartholomeu DC, Giunchetti RC, Bueno LL, Correa-Oliveira R, Nakhasi HL, Fujiwara RT

Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum.

Vaccine. 2014;33(2):280-8 - PMID: 25475955 - DOI: 10.1016/j.vaccine.2014.11.039

Coelho-dos-Reis JG, Passos L, Duarte MC, Araújo MG, Campi-Azevedo AC, Teixeira-Carvalho A, Peruhype-Magalhães V, Trindade BC, Dos Santos Dias R, Martins ML, Carneiro-Proietti AB, Guedes AC, Gonçalves DU, Martins-Filho OA

Immunological profile of HTLV-1-infected patients associated with infectious or autoimmune dermatological disorders.

PLoS Negl Trop Dis. 2013;7(7):e2328 - PMID: 23936564 - PMCID: PMC3723575 - DOI: 10.1371/journal.pntd.0002328

Gazzinelli-Guimarães PH, Gazzinelli-Guimarães AC, Silva FN, Mati VL, Dhom-Lemos Lde C, Barbosa FS, Passos LS, Gaze S, Carneiro CM, Bartholomeu DC, Bueno LL, Fujiwara RT

Parasitological and immunological aspects of early Ascaris spp. infection in mice.

Int J Parasitol. 2013;43(9):697-706 - PMID: 23665127 - DOI: 10.1016/j.ijpara.2013.02.009