Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital

Katsuki, Shunsuke

Katsuki, Shunsuke

Research Fellow


Dr. Shunsuke Katsuki graduated from Kyushu University School of Medicine in Fukuoka, Japan in 2005. He started his career as a physician at Kyushu University Hospital where he specialized in Cardiology after two years of general training. In 2008, he entered the graduate program at the Department of Cardiovascular Medicine, Kyushu University. There he worked in vascular biology and investigated the basic mechanism of atherosclerosis and its clinical translation to develop a novel nanoparticle-mediated drug delivery system for acute coronary syndrome. He demonstrated using murine plaque rupture model, nanoparticle-mediated delivery of statin inhibits atherosclerotic plaque destabilization and rupture. He published this result in the most authoritative scientific journal, Circulation, and earned the doctoral degree in 2014. He received ATVB Travel Awards for Young Investigators from American Heart Association in 2010 and Young Investigator’s Award from Japanese Circulation Society in 2012. He was funded by Banyu Life Science Foundation International and is now funded by Japan Society for the Promotion of Science.

He is also a Board Certified Member of the Japanese Society of Internal Medicine and Japanese Circulation Society. He has abundantly experienced various cardiovascular diseases as a medical staff in the cardiovascular department at Kyushu University Hospital from 2012 until 2014 and as a medical director in the department of cardiology, Japan Community Healthcare Organization Kyushu Hospital from 2014 until September 2015.
He started working as a research fellow in the Center for Excellence in Vascular Biology, Cardiovascular Medicine, at Brigham and Women’s Hospital on October 5, 2015.


Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabasi AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M
Uremic Toxin Indoxyl Sulfate Promotes Pro-Inflammatory Macrophage Activation via the Interplay of OATB2B1 and Dll4-Notch Signaling: Potential Mechanism for Accelerated Atherogenesis in Chronic Kidney Disease.
Circulation. 2018;:ePub - PMID: 30586693 - PMCID: PMC6311723 - DOI: 10.1161/CIRCULATIONAHA.118.034588
Fujino T, Inoue S, Katsuki S, Higo T, Ide T, Oda Y, Tsutsui H
Fatal Cardiac Hemochromatosis in a Patient with Hereditary Spherocytosis.
Int Heart J. 2018;59(2):427-430 - PMID: 29563373 - DOI: 10.1536/ihj.17-160
Katsuki S, Matoba T, Koga JI, Nakano K, Egashira K
Anti-inflammatory Nanomedicine for Cardiovascular Disease.
Front Cardiovasc Med. 2017;4:87 - PMID: 29312961 - PMCID: PMC5743792 - DOI: 10.3389/fcvm.2017.00087
Tadokoro T, Katsuki S, Ito K, Onitsuka K, Nakashima A, Sasaguri T, Miyata K, Yamamoto H, Mohri M
Inoperable Primary Ovarian Carcinoid Led to the Progression of Carcinoid Heart Disease From Right-Sided to Both-Sided Involvement.
Circ Heart Fail. 2017;10(1):ePub - PMID: 28069686 - DOI: 10.1161/CIRCHEARTFAILURE.116.003719
Takase S, Matoba T, Nakashiro S, Mukai Y, Inoue S, Oi K, Higo T, Katsuki S, Takemoto M, Suematsu N, Eshima K, Miyata K, Yamamoto M, Usui M, Sadamatsu K, Satoh S, Kadokami T, Hironaga K, Ichi I, Todaka K, Kishimoto J, Egashira K, Sunagawa K.
Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial.
Arterioscler Thromb Vasc Biol. 2016;37(2):350-358 - PMID: 27932353 - DOI: 10.1161/ATVBAHA.116.308388
Nakano Y, Matoba T, Tokutome M, Funamoto D, Katsuki S, Ikeda G, Nagaoka K, Ishikita A, Nakano K, Koga J, Sunagawa K, Egashira K
Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.
Sci Rep. 2016;6:29601 - PMID: 27403534 - PMCID: PMC4939605 - DOI: 10.1038/srep29601
Nakashiro S, Matoba T, Umezu R, Koga JI, Tokutome M, Katsuki S, Nakano K, Sunagawa K, Egashira K
Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice.
Arterioscler Thromb Vasc Biol. 2016;36(3):491-500 - PMID: 26821947 - DOI: 10.1161/ATVBAHA.115.307057
Katsuki S, Ito K, Tadokoro T, Sasaguri T, Hisahara M, Mohri M
Mitral annulus calcification-related calcified amorphous tumour trapped and extended by closing aortic valve.
Eur Heart J Cardiovasc Imaging. 2016;17(5):585 - PMID: 26787612 - DOI: 10.1093/ehjci/jev349
Katsuki S, Matoba T, Nakashiro S, Sato K, Koga J, Nakano K, Nakano Y, Egusa S, Sunagawa K, Egashira K
Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes.
Circulation. 2013;129(8):896-906 - PMID: 24305567 - DOI: 10.1161/CIRCULATIONAHA.113.002870
Sato K, Nakano K, Katsuki S, Matoba T, Osada K, Sawamura T, Sunagawa K, Egashira K
Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
J Atheroscler Thromb. 2012;19(11):986-98 - PMID: 22785139