Aikawa-Aikawa Laboratories

Katsuki, Shunsuke

Research Fellow

(617)525-4385

skatsuki@bwh.harvard.edu

Dr. Shunsuke Katsuki graduated from Kyushu University School of Medicine in Fukuoka, Japan in 2005. He started his career as a physician at Kyushu University Hospital where he specialized in Cardiology after two years of general training. In 2008, he entered the graduate program at the Department of Cardiovascular Medicine, Kyushu University. There he worked in vascular biology and investigated the basic mechanism of atherosclerosis and its clinical translation to develop a novel nanoparticle-mediated drug delivery system for acute coronary syndrome. He demonstrated using murine plaque rupture model, nanoparticle-mediated delivery of statin inhibits atherosclerotic plaque destabilization and rupture. He published this result in the most authoritative scientific journal, Circulation, and earned the doctoral degree in 2014. He received ATVB Travel Awards for Young Investigators from American Heart Association in 2010 and Young Investigator’s Award from Japanese Circulation Society in 2012. He was funded by Banyu Life Science Foundation International and is now funded by Japan Society for the Promotion of Science.

He is also a Board Certified Member of the Japanese Society of Internal Medicine and Japanese Circulation Society. He has abundantly experienced various cardiovascular diseases as a medical staff in the cardiovascular department at Kyushu University Hospital from 2012 until 2014 and as a medical director in the department of cardiology, Japan Community Healthcare Organization Kyushu Hospital from 2014 until September 2015.
He started working as a research fellow in the Center for Excellence in Vascular Biology, Cardiovascular Medicine, at Brigham and Women’s Hospital on October 5, 2015.

Publications

Katsuki S, Jha PK, Aikawa E, Aikawa M

The role of proprotein convertase subtilisin/kexin 9 (PCSK9) in macrophage activation: a focus on its LDL receptor-independent mechanisms.

Front Cardiovasc Med. 2024;11:1431398 - PMID: 39149582 - PMCID: PMC11324467 - DOI: 10.3389/fcvm.2024.1431398

Katsuki S, Kumar Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, Vittorio Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M

Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.

Circ Res. 2022;131(11):873-889 - PMID: 36263780 - PMCID: PMC9973449 - DOI: 10.1161/CIRCRESAHA.121.320056

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):178-180 - PMID: 32619513 - DOI: 10.1016/j.stem.2020.05.013

Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E

S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.

Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Torsten M, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):147-157.e7 - PMID: 32413331 - PMCID: PMC8530449 - DOI: 10.1016/j.stem.2020.04.018

Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabasi AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M

Uremic Toxin Indoxyl Sulfate Promotes Pro-Inflammatory Macrophage Activation via the Interplay of OATB2B1 and Dll4-Notch Signaling: Potential Mechanism for Accelerated Atherogenesis in Chronic Kidney Disease.

Circulation. 2018;139(1):78-96 - PMID: 30586693 - PMCID: PMC6311723 - DOI: 10.1161/CIRCULATIONAHA.118.034588

Fujino T, Inoue S, Katsuki S, Higo T, Ide T, Oda Y, Tsutsui H

Fatal Cardiac Hemochromatosis in a Patient with Hereditary Spherocytosis.

Int Heart J. 2018;59(2):427-430 - PMID: 29563373 - DOI: 10.1536/ihj.17-160

Katsuki S, Matoba T, Koga JI, Nakano K, Egashira K

Anti-inflammatory Nanomedicine for Cardiovascular Disease.

Front Cardiovasc Med. 2017;4:87 - PMID: 29312961 - PMCID: PMC5743792 - DOI: 10.3389/fcvm.2017.00087

Tadokoro T, Katsuki S, Ito K, Onitsuka K, Nakashima A, Sasaguri T, Miyata K, Yamamoto H, Mohri M

Inoperable Primary Ovarian Carcinoid Led to the Progression of Carcinoid Heart Disease From Right-Sided to Both-Sided Involvement.

Circ Heart Fail. 2017;10(1):ePub - PMID: 28069686 - DOI: 10.1161/CIRCHEARTFAILURE.116.003719

Takase S, Matoba T, Nakashiro S, Mukai Y, Inoue S, Oi K, Higo T, Katsuki S, Takemoto M, Suematsu N, Eshima K, Miyata K, Yamamoto M, Usui M, Sadamatsu K, Satoh S, Kadokami T, Hironaga K, Ichi I, Todaka K, Kishimoto J, Egashira K, Sunagawa K.

Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial.

Arterioscler Thromb Vasc Biol. 2016;37(2):350-358 - PMID: 27932353 - DOI: 10.1161/ATVBAHA.116.308388

Nakano Y, Matoba T, Tokutome M, Funamoto D, Katsuki S, Ikeda G, Nagaoka K, Ishikita A, Nakano K, Koga J, Sunagawa K, Egashira K

Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.

Sci Rep. 2016;6:29601 - PMID: 27403534 - PMCID: PMC4939605 - DOI: 10.1038/srep29601

Nakashiro S, Matoba T, Umezu R, Koga JI, Tokutome M, Katsuki S, Nakano K, Sunagawa K, Egashira K

Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice.

Arterioscler Thromb Vasc Biol. 2016;36(3):491-500 - PMID: 26821947 - DOI: 10.1161/ATVBAHA.115.307057

Katsuki S, Ito K, Tadokoro T, Sasaguri T, Hisahara M, Mohri M

Mitral annulus calcification-related calcified amorphous tumour trapped and extended by closing aortic valve.

Eur Heart J Cardiovasc Imaging. 2016;17(5):585 - PMID: 26787612 - DOI: 10.1093/ehjci/jev349

Katsuki S, Matoba T, Nakashiro S, Sato K, Koga J, Nakano K, Nakano Y, Egusa S, Sunagawa K, Egashira K

Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes.

Circulation. 2013;129(8):896-906 - PMID: 24305567 - DOI: 10.1161/CIRCULATIONAHA.113.002870

Sato K, Nakano K, Katsuki S, Matoba T, Osada K, Sawamura T, Sunagawa K, Egashira K

Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.

J Atheroscler Thromb. 2012;19(11):986-98 - PMID: 22785139 - DOI: 10.5551/jat.13391