Aikawa-Aikawa Laboratories

Nakano, Toshiaki

Research Fellow

(617) 525-4387

tnakano1@bwh.harvard.edu

Dr. Toshiaki Nakano graduated from Kumamoto University School of Medicine in Kumamoto Japan in 1998. He started his career as a physician at Kyushu University Hospital where he specialized in Nephrology after two years of general training. In 2002, he entered into the Department of Pathophysiological and Experimental Pathology at Kyushu University. There he worked in vascular biology, especially in atherosclerosis, angiogenesis and chronic kidney disease. He also learned fundamental techniques of biochemistry and pathology and finished his Phd in 2006.
He treated many patients with kidney diseases and cardiovascular diseases as an Assistant Professor in the Kidney Care Unit at the Kyushu University Hospital from 2010 until 2013. He received the Excellent Award of Japanese Society of Nephrology in 2011. He was funded by the International Research Fund for Subsidy of Kyushu University School of Medicine Alumni.
He moved to the U.S to work as a research fellow in the Center for Excellence in Vascular Biology, Cardiovascular Medicine, at Brigham and Women’s Hospital on January 2, 2014.

Publications

Katsuki S, Kumar Jha P, Lupieri A, Nakano T, Passos LSA, Rogers MA, Becker-Greene D, Le TD, Decano JL, Ho Lee L, Guimaraes GC, Abdelhamid I, Halu A, Muscoloni A, Vittorio Cannistraci C, Higashi H, Zhang H, Vromman A, Libby P, Keith Ozaki C, Sharma A, Singh SA, Aikawa E, Aikawa M

Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.

Circ Res. 2022;131(11):873-889 - PMID: 36263780 - PMCID: PMC9973449 - DOI: 10.1161/CIRCRESAHA.121.320056

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):178-180 - PMID: 32619513 - DOI: 10.1016/j.stem.2020.05.013

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Torsten M, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):147-157.e7 - PMID: 32413331 - PMCID: PMC8530449 - DOI: 10.1016/j.stem.2020.04.018

Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabasi AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M

Uremic Toxin Indoxyl Sulfate Promotes Pro-Inflammatory Macrophage Activation via the Interplay of OATB2B1 and Dll4-Notch Signaling: Potential Mechanism for Accelerated Atherogenesis in Chronic Kidney Disease.

Circulation. 2018;139(1):78-96 - PMID: 30586693 - PMCID: PMC6311723 - DOI: 10.1161/CIRCULATIONAHA.118.034588

Nakano T, Fukuda D, Koga JI, Aikawa M

Delta-Like Ligand 4-Notch Signaling in Macrophage Activation.

Arterioscler Thromb Vasc Biol. 2016;36(10):2038-47 - PMID: 27562914 - PMCID: PMC5033717 - DOI: 10.1161/ATVBAHA.116.306926

Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.

Arterioscler Thromb Vasc Biol. 2015;35(11):2343-2353 - PMID: 26404485 - PMCID: PMC5003117 - DOI: 10.1161/ATVBAHA.115.305516

Fujisaki K, Tsuruya K, Nakano T, Taniguchi M, Higashi H, Katafuchi R, Kanai H, Nakayama M, Hirakata H, Kitazono T

Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension.

Hypertens Res. 2014;37(11):993-8 - PMID: 24965167 - DOI: 10.1038/hr.2014.110

Yamada S, Tokumoto M, Tatsumoto N, Taniguchi M, Noguchi H, Nakano T, Masutani K, Ooboshi H, Tsuruya K, Kitazono T

Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia.

Am J Physiol Renal Physiol. 2014;306(12):F1418-28 - PMID: 24808541 - DOI: 10.1152/ajprenal.00633.2013

Yamada S, Tsuruya K, Taniguchi M, Yoshida H, Tokumoto M, Hasegawa S, Tanaka S, Eriguchi M, Nakano T, Kitazono T

Relationship Between Residual Renal Function and Serum Fibroblast Growth Factor 23 in Patients on Peritoneal Dialysis.

Ther Apher Dial. 2014;18(5):383-90 - PMID: 24674095 - DOI: 10.1111/1744-9987.12170

Fujisaki K, Tsuruya K, Yamato M, Toyonaga J, Noguchi H, Nakano T, Taniguchi M, Tokumoto M, Hirakata H, Kitazono T

Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol.

Nephrol Dial Transplant. 2013;29(3):529-38 - PMID: 24030834 - DOI: 10.1093/ndt/gft327

Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y

Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study.

Kidney Int. 2013;84(2):373-80 - PMID: 23594677 - DOI: 10.1038/ki.2013.111

Yamada S, Tsuruya K, Yoshida H, Taniguchi M, Haruyama N, Tanaka S, Eriguchi M, Nakano T, Kitazono T

The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis.

Clin Endocrinol (Oxf). 2013;78(6):844-51 - PMID: 23078546 - DOI: 10.1111/cen.12070

Yamada S, Yoshida H, Taniguchi M, Tanaka S, Eriguchi M, Nakano T, Tsuruya K, Kitazono T

Effectiveness of lanthanum carbonate treatment used in combination with other phosphate binders in peritoneal dialysis patients.

Intern Med. 2012;51(16):2097-104 - PMID: 22892485 - DOI: 10.2169/internalmedicine.51.6814

Eriguchi M, Tsuruya K, Yoshida H, Yamada S, Tanaka S, Suehiro T, Nakano T, Taniguchi M

Validation of the exit-site scoring system recommended by the 2005 guidelines of the International Society for Peritoneal Dialysis.

Perit Dial Int. 2011;31(6):698-700 - PMID: 22123857 - DOI: 10.3747/pdi.2010.00287

Matsuura M, Onimaru M, Yonemitsu Y, Suzuki H, Nakano T, Ishibashi H, Shirasuna K, Sueishi K

Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells.

Am J Pathol. 2009;175(4):1709-21 - PMID: 19779139 - PMCID: PMC2751566 - DOI: 10.2353/ajpath.2009.081139

Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, Tsuruya K, Iida M, Kiyohara Y, Sueishi K

Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study.

Am J Kidney Dis. 2009;55(1):21-30 - PMID: 19765871 - DOI: 10.1053/j.ajkd.2009.06.034

Onimaru M, Yonemitsu Y, Fujii T, Tanii M, Nakano T, Nakagawa K, Kohno R, Hasegawa M, Nishikawa S, Sueishi K

VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B.

Am J Physiol Heart Circ Physiol. 2009;297(5):H1685-96 - PMID: 19734356 - DOI: 10.1152/ajpheart.00015.2009

Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y

A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.

Nat Genet. 2007;39(2):212-7 - PMID: 17206144 - DOI: 10.1038/ng1945

Aishima M, Tomoda T, Yunoki T, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N

Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.

Br J Pharmacol. 2006;149(5):542-50 - PMID: 17016513 - PMCID: PMC2014675 - DOI: 10.1038/sj.bjp.0706893

Fujii T, Yonemitsu Y, Onimaru M, Tanii M, Nakano T, Egashira K, Takehara T, Inoue M, Hasegawa M, Kuwano H, Sueishi K

Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway.

Arterioscler Thromb Vasc Biol. 2006;26(11):2483-9 - PMID: 16960104 - DOI: 10.1161/01.ATV.0000244684.23499.bf

Ikeda Y, Yonemitsu Y, Onimaru M, Nakano T, Miyazaki M, Kohno R, Nakagawa K, Ueno A, Sueishi K, Ishibashi T

The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium.

Exp Eye Res. 2006;83(5):1031-40 - PMID: 16842779 - DOI: 10.1016/j.exer.2006.05.007

Tomoda T, Aishima M, Takano N, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N

The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder.

Br J Pharmacol. 2005;146(1):25-32 - PMID: 15965499 - PMCID: PMC1576239 - DOI: 10.1038/sj.bjp.0706284

Shikada Y, Yonemitsu Y, Koga T, Onimaru M, Nakano T, Okano S, Sata S, Nakagawa K, Yoshino I, Maehara Y, Sueishi K

Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas.

Cancer Res. 2005;65(16):7241-8 - PMID: 16103075 - DOI: 10.1158/0008-5472.CAN-04-4171

Baba H, Yonemitsu Y, Nakano T, Onimaru M, Miyazaki M, Ikeda Y, Sumiyoshi S, Ueda Y, Hasegawa M, Yoshino I, Maehara Y, Sueishi K

Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques.

Arterioscler Thromb Vasc Biol. 2005;25(9):1938-44 - PMID: 15994443 - DOI: 10.1161/01.ATV.0000175759.78338.1e

Nakano T, Nakashima Y, Yonemitsu Y, Sumiyoshi S, Chen YX, Akishima Y, Ishii T, Iida M, Sueishi K

Angiogenesis and lymphangiogenesis and expression of lymphangiogenic factors in the atherosclerotic intima of human coronary arteries.

Hum Pathol. 2005;36(4):330-40 - PMID: 15891993 - DOI: 10.1016/j.humpath.2005.01.001