Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital
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Raju S, Botts SR, Blaser MC, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL
Directional Endothelial Communication by Polarized Extracellular Vesicle Release.
Circ Res. 2024;:ePub - PMID: 38174557 - DOI: 10.1161/CIRCRESAHA.123.322993
Turner ME, Beck L, Hill Gallant KM, Chen Y, Moe OW, Kuro-O M, Moe S, Aikawa E
Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.
Arterioscler Thromb Vasc Biol. 2024;:ePub - PMID: 38205639 - DOI: 10.1161/ATVBAHA.123.319198
Kumar Jha P, Aikawa M, Aikawa E
Macrophage Heterogeneity and Efferocytosis: Beyond the M1/M2 Dichotomy.
Circ Res. 2024;134(2):186-188 - PMID: 38236949 - DOI: 10.1161/CIRCRESAHA.123.324011
Shelbaya K, Arthur V, Yang Y, Dorbala P, Buckley L, Claggett B, Skali H, Dufresne L, Yang TY, Engert JC, Thanassoulis G, Floyd J, Austin TR, Bortnick A, Kizer J, Freitas RCC, Singh SA, Aikawa E, Hoogeveen RC, Ballantyne C, Yu B, Coresh J, Blaha MJ, Matsushita K, Shah AM
Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis.
J Am Coll Cardiol. 2024;83(5):577-591 - PMID: 38296402 - DOI: 10.1016/j.jacc.2023.11.021
Jansen I, Cahalane R, Hengst R, Akyildiz A, Farrell E, Gijsen F, Aikawa E, van der Heiden K, Wissing T
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics.
Basic Res Cardiol. 2024;:ePub - PMID: 38329498 - DOI: 10.1007/s00395-024-01033-5
Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E
Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum.
Arterioscler Thromb Vasc Biol. 2024;:ePub - PMID: 38357818 - DOI: 10.1161/ATVBAHA.124.320708
Clift CL, Blaser MC, Gerrits W, Turner ME, Sonawane A, Pham T, Andresen JL, Fenton OS, Grolman JM, Campedelli A, Buffolo F, Schoen FJ, Hjortnaes J, Muehlschlegel JD, Mooney DJ, Aikawa M, Singh SA, Langer R, Aikawa E
Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays.
Sci Adv. 2024;10(9):eadj9793 - PMID: 38416823 - DOI: 10.1126/sciadv.adj9793
Cahalane RME, Turner ME, Clift CL, Blaser MC, Bogut G, Levy S, Kasai T, Driedonks TAP, Nolte-'t Hoen ENM, Aikawa M, Singh SA, Aikawa E
Polycarbonate Ultracentrifuge Tube Re-use in Proteomic Analyses of Extracellular Vesicles.
J Vis Exp. 2024;(205):ePub - PMID: 38526125 - DOI: 10.3791/66126
Aikawa E, Blaser MC, Singh SA, Levine RA, Yacoub MH
Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community.
Arterioscler Thromb Vasc Biol. 2024;44(4):763-767 - PMID: 38536897 - PMCID: PMC10977651 - DOI: 10.1161/ATVBAHA.123.319563
Reyes-Soffer G, Matveyenko A, Lignos J, Matienzo N, Santos Baez LS, Hernandez-One A, Yung L, Nandakumar R, Singh SA, Aikawa M, George R, Ginsberg HN
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans.
Arterioscler Thromb Vasc Biol. 2024;:ePub - PMID: 38695168 - DOI: 10.1161/ATVBAHA.123.320387
Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR
PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.
bioRxiv. 2024;:ePub - PMID: 38712082 - PMCID: PMC11071520 - DOI: 10.1101/2024.04.26.591186
Gordon LB, Basso S, Maestranzi J, Aikawa E, Clift CL, Cammardella AG, Danesi TH, Del Nido PJ, Edelman ER, Hamdy A, Hegde SM, Kleinman ME, Maschietto N, Mehra MR, Mukundan S, Musumeci F, Russo M, Rybicki FJ, Shah PB, Suarez WA, Tuminelli K, Zaleski K, Prakash A, Gerhard-Herman M
Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome.
Front Cardiovasc Med. 2024;11:1356010 - PMID: 38725831 - PMCID: PMC11079313 - DOI: 10.3389/fcvm.2024.1356010
Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C, American Heart Association Council on Genomic and Precision Medicine Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing
Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association.
Circulation. 2024;:ePub - PMID: 38881493 - DOI: 10.1161/CIR.0000000000001254
Aikawa E, Allison MA, Iruela Arispe L, Bendeck MP, Chen Y, Gardiner EE, Golledge J, Suzuki-Inoue K, Marelli-Berg F, Powell JT, Ramasamy R, Sarpong DF, Sorci-Thomas MG, Daugherty A, Hegele RA, Schmidt AM
Honoring the Life and Legacy of Dr David A. Dichek.
Arterioscler Thromb Vasc Biol. 2024;44(7):1459-1461 - PMID: 38924433 - DOI: 10.1161/ATVBAHA.124.321293
Chen ZB, Aikawa E, Alfaidi M, Ali K, Clift CL, Erbay E, Fredman G, Gomez D, Huang NF, Lu HS, Nguyen PK, Darc Oliveira S, Rodriguez-Miguelez P, SenthilKumar G, Zhang H, by the ATVB WLC
Institutional Support for the Career Advancement of Women Faculty in Science and Academic Medicine: Successes, Challenges, and Future Directions.
Arterioscler Thromb Vasc Biol. 2024;:ePub - PMID: 38957985 - DOI: 10.1161/ATVBAHA.124.320910
Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RM, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman M, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL
Multi-omic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks.
bioRxiv. 2024;:ePub - PMID: 38979218 - PMCID: PMC11230219 - DOI: 10.1101/2024.06.21.599781
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, gael.cagnone.1@gmail.com, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Res Sq. 2024;:ePub - PMID: 38978601 - PMCID: PMC11230485 - DOI: 10.21203/rs.3.rs-4619093/v1
Okui T, Kuraoka S, Iwashita M, Itagawa R, Kasai T, Aikawa M, Singh SA, Aikawa E
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids.
Front Mol Biosci. 2024;11:1374316 - PMID: 39076376 - PMCID: PMC11284101 - DOI: 10.3389/fmolb.2024.1374316
Yagi H, Boeck M, Nian S, Neilsen K, Wang C, Lee J, Zeng Y, Grumbine M, Sweet IR, Kasai T, Negishi K, Singh SA, Aikawa M, Hellström A, Smith LEH, Fu Z
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Angiogenesis. 2024;:ePub - PMID: 39096357 - DOI: 10.1007/s10456-024-09940-w
Katsuki S, Jha PK, Aikawa E, Aikawa M
The role of proprotein convertase subtilisin/kexin 9 (PCSK9) in macrophage activation: a focus on its LDL receptor-independent mechanisms.
Front Cardiovasc Med. 2024;11:1431398 - PMID: 39149582 - PMCID: PMC11324467 - DOI: 10.3389/fcvm.2024.1431398
Delwarde C, Aikawa M
Novel Mouse Model of Late-Stage Coronary Atherosclerosis With Features of Plaque Rupture and Stroke.
Circulation. 2024;150(9):706-709 - PMID: 39186532 - DOI: 10.1161/CIRCULATIONAHA.124.070464
Matamalas JT, Chelvanambi S, Decano JL, França RF, Halu A, Santinelli-Pestana DV, Aikawa E, Malhotra R, Aikawa M
Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals.
PNAS Nexus. 2024;3(8):pgae294 - PMID: 39192848 - PMCID: PMC11348562 - DOI: 10.1093/pnasnexus/pgae294
Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Wei W, Aikawa M, Shi J, Chen H
Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing.
bioRxiv. 2024;:ePub - PMID: 39253510 - PMCID: PMC11383039 - DOI: 10.1101/2024.02.07.579019
Peng Q, Arulsamy K, Lu YW, Wu H, Zhu B, Singh B, Cui K, Wylie-Sears J, Li K, Wong S, Cowan DB, Aikawa M, Wang DZ, Bischoff J, Chen K, Chen H
Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis.
bioRxiv. 2024;:ePub - PMID: 39282400 - PMCID: PMC11398423 - DOI: 10.1101/2024.09.03.610974
Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, Neilsen K, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.
Angiogenesis. 2024;:ePub - PMID: 39287727 - DOI: 10.1007/s10456-024-09948-2
Garelnabi M, Ntsekhe M, Doubell A, Aikawa M
Editorial: Global Excellence in Cardiovascular Medicine in Africa: challenges and opportunities.
Front Cardiovasc Med. 2024;11:1479281 - PMID: 39502195 - PMCID: PMC11534761 - DOI: 10.3389/fcvm.2024.1479281
Iwata A, Chelvanambi S, Asano T, Whelan M, Nakamura Y, Aikawa E, Sasaki Y, Aikawa M
Gene expression profiles of precursor cells identify compounds that reduce NRP1 surface expression in macrophages: Implication for drug repositioning for COVID-19.
Front Cardiovasc Med. 2024;11:1438396 - PMID: 39512370 - PMCID: PMC11541348 - DOI: 10.3389/fcvm.2024.1438396
Kip P, Sluiter TJ, MacArthur MR, Tao M, Kruit N, Mitchell SJ, Jung J, Kooijman S, Gorham J, Seidman JG, Quax PHA, Decano JL, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR
Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice.
Nat Commun. 2024;15(1):9652 - PMID: 39511181 - DOI: 10.1038/s41467-024-53844-8
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