Aikawa-Aikawa Laboratories

Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E

18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.

Circ Cardiovasc Imaging. 2019;12(1):e007835 - PMID: 30642216 - PMCID: PMC6338081 - DOI: 10.1161/CIRCIMAGING.118.007835

Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH

Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.

J Am Coll Cardiol. 2019;73(2):190-209 - PMID: 30654892 - PMCID: PMC6865825 - DOI: 10.1016/j.jacc.2018.09.089

Blaser MC, Aikawa E

Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis.

Circ Res. 2019;124(4):467-469 - PMID: 30763209 - PMCID: PMC6383776 - DOI: 10.1161/CIRCRESAHA.119.314596

Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR

After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.

Front Cardiovasc Med. 2019;6:8 - PMID: 30838213 - PMCID: PMC6382669 - DOI: 10.3389/fcvm.2019.00008

Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M

A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation.

J Proteome Res. 2019;18(4):1607-1622 - PMID: 30848916 - PMCID: PMC6456868 - DOI: 10.1021/acs.jproteome.8b00895

Phillippi JA, Aikawa E, Hutcheson J

Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine.

Front Cardiovasc Med. 2019;6:13 - PMID: 30873414 - PMCID: PMC6401650 - DOI: 10.3389/fcvm.2019.00013

Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E

Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification.

Front Cardiovasc Med. 2019;6:49 - PMID: 31041314 - PMCID: PMC6476921 - DOI: 10.3389/fcvm.2019.00049

Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR

Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis.

J Am Coll Cardiol. 2019;73(17):2150-2162 - PMID: 31047003 - PMCID: PMC6494952 - DOI: 10.1016/j.jacc.2019.01.070

Grunewald ME, Chen Y, Kuny C, Maejima T, Lease R, Ferraris D, Aikawa M, Sullivan CS, Perlman S, Fehr AR

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

PLoS Pathog. 2019;15(5):e1007756 - PMID: 31095648 - PMCID: PMC6521996 - DOI: 10.1371/journal.ppat.1007756

Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoğlu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.

Cardiovasc Diabetol. 2019;18(1):71 - PMID: 31164165 - PMCID: PMC6549355 - DOI: 10.1186/s12933-019-0864-7

Passos LSA, Magalhães LMD, Soares RP, Marques AF, Alves MLR, Giunchetti RC, Nunes MDCP, Gollob KJ, Dutra WO

Corrigendum: Activation of Human CD11b⁺ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease.

Front Immunol. 2019;10:367 - PMID: 30891038 - PMCID: PMC6412107 - DOI: 10.3389/fimmu.2019.00367

Guimarães Júnior MH, Ferrari TCA, Teixeira-Carvalho A, Moreira ML, de Souza Santos LJ, Costa-Silva MF, Coelho RMP, Pinto PHOM, Ris TH, Salles JT, Passos LSA, Nunes MCP

Cell-derived microvesicles in infective endocarditis: role in diagnosis and potential for risk stratification at hospital admission.

J Infect. 2019;79(2):101-107 - PMID: 31207323 - DOI: 10.1016/j.jinf.2019.06.005

Diamantino Soares AC, Araújo Passos LS, Sable C, Beaton A, Ribeiro VT, Gollob KJ, Dutra WO, Nunes MCP

Circulating cytokines predict severity of rheumatic heart disease.

Int J Cardiol. 2019;289:107-109 - PMID: 31079974 - DOI: 10.1016/j.ijcard.2019.04.063

Atkins SK, Aikawa E

Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms.

Heart. 2019;105(21):1610-1611 - PMID: 31296591 - PMCID: PMC6855786 - DOI: 10.1136/heartjnl-2019-315236

Magalhães LMD, Passos LSA, Chiari E, Galvão LMC, Koh CC, Rodrigues-Alves ML, Giunchetti RC, Gollob K, Dutra WO

Co-infection with distinct Trypanosoma cruzi strains induces an activated immune response in human monocytes.

Parasite Immunol. 2019;41(11):e12668 - PMID: 31494949 - PMCID: PMC6800597 - DOI: 10.1111/pim.12668

Rogers MA, Aikawa E

MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk.

Arterioscler Thromb Vasc Biol. 2019;39(12):2448-2450 - PMID: 31770027 - PMCID: PMC6980729 - DOI: 10.1161/ATVBAHA.119.313533

Nakato R, Wada Y, Nakaki R, Nagae G, Katou Y, Tsutsumi S, Nakajima N, Fukuhara H, Iguchi A, Kohro T, Kanki Y, Saito Y, Kobayashi M, Izumi-Taguchi A, Osato N, Tatsuno K, Kamio A, Hayashi-Takanaka Y, Wada H, Ohta S, Aikawa M, Nakajima H, Nakamura M, McGee RC, Heppner KW, Kawakatsu T, Genno M, Yanase H, Kume H, Senbonmatsu T, Homma Y, Nishimura S, Mitsuyama T, Aburatani H, Kimura H, Shirahige K

Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.

Epigenetics Chromatin. 2019;12(1):77 - PMID: 31856914 - PMCID: PMC6921469 - DOI: 10.1186/s13072-019-0319-0