Aikawa-Aikawa Laboratories

Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J

Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.

J Am Coll Cardiol. 2020;75(4):395-405 - PMID: 32000951 - PMCID: PMC7946170 - DOI: 10.1016/j.jacc.2019.11.039

Fehr AR, Singh SA, Kerr CM, Mukai S, Higashi H, Aikawa M

The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions.

Genes Dev. 2020;34(5-6):341-359 - PMID: 32029454 - PMCID: PMC7050484 - DOI: 10.1101/gad.334425.119

Rogers MA, Aikawa E

Complex association of lipoprotein(a) with aortic stenosis.

Heart. 2020;106(10):711-712 - PMID: 32086294 - DOI: 10.1136/heartjnl-2019-316498

Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.

Elife. 2020;9:ePub - PMID: 32091396 - PMCID: PMC7054001 - DOI: 10.7554/eLife.52690

Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS

A durable murine model of spleen transplantation with arterial and venous anastomoses.

Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7

Passos LSA, Lupieri A, Becker-Greene D, Aikawa E

Innate and adaptive immunity in cardiovascular calcification.

Atherosclerosis. 2020;306:59-67 - PMID: 32222287 - PMCID: PMC7483874 - DOI: 10.1016/j.atherosclerosis.2020.02.016

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Torsten M, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):147-157.e7 - PMID: 32413331 - PMCID: PMC8530449 - DOI: 10.1016/j.stem.2020.04.018

Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E

S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus.

Arterioscler Thromb Vasc Biol. 2020;40(8):1838-1853 - PMID: 32460581 - PMCID: PMC7377960 - DOI: 10.1161/ATVBAHA.118.314087

Bartoli-Leonard F, Saddic L, Aikawa E

Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system.

Eur Heart J. 2020;41(26):2453-2455 - PMID: 32585692 - PMCID: PMC7340353 - DOI: 10.1093/eurheartj/ehaa444

Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Cell Stem Cell. 2020;27(1):178-180 - PMID: 32619513 - DOI: 10.1016/j.stem.2020.05.013

Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR

Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis.

Atherosclerosis. 2020;307:16-20 - PMID: 32702536 - PMCID: PMC7583087 - DOI: 10.1016/j.atherosclerosis.2020.06.019

Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E

Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.

Sci Adv. 2020;6(38):ePub - PMID: 32938681 - PMCID: PMC7494353 - DOI: 10.1126/sciadv.abb1244

Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J

Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes.

JACC Cardiovasc Imaging. 2020;13(12):2513-2526 - PMID: 32950446 - PMCID: PMC7861508 - DOI: 10.1016/j.jcmg.2020.07.020

Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Cytokine Growth Factor Rev. 2020;58:102-110 - PMID: 32988728 - PMCID: PMC7505161 - DOI: 10.1016/j.cytogfr.2020.09.002

Rogers MA, Aikawa E

An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease.

JACC Basic Transl Sci. 2020;5(9):898-900 - PMID: 33016951 - PMCID: PMC7524779 - DOI: 10.1016/j.jacbts.2020.04.016

Aikawa E, Blaser MC

2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders.

Arterioscler Thromb Vasc Biol. 2020;41(1):117-127 - PMID: 33115271 - PMCID: PMC7832175 - DOI: 10.1161/ATVBAHA.120.314704

Bartoli-Leonard F, Aikawa E

Heart Valve Disease: Challenges and New Opportunities.

Front Cardiovasc Med. 2020;7:602271 - PMID: 33195488 - PMCID: PMC7642276 - DOI: 10.3389/fcvm.2020.602271

Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E

ApoC-III is a novel inducer of calcification in human aortic valves.

J Biol Chem. 2020;296:100193 - PMID: 33334888 - PMCID: PMC7948477 - DOI: 10.1074/jbc.RA120.015700

Iqbal F, Lupieri A, Aikawa M, Aikawa E

Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.

Arterioscler Thromb Vasc Biol. 2020;41(2):585-600 - PMID: 33327741 - PMCID: PMC8105278 - DOI: 10.1161/ATVBAHA.120.314776

Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E

CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.

Arterioscler Thromb Vasc Biol. 2020;41(2):755-768 - PMID: 33356393 - PMCID: PMC8105275 - DOI: 10.1161/ATVBAHA.120.315007

Singh SA, Andraski AB, Higashi H, Lee LH, Ramsaroop A, Sacks FM, Aikawa M

Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos.

JCI Insight. 2020;:ePub - PMID: 33351780 - PMCID: PMC7934878 - DOI: 10.1172/jci.insight.143526

Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E

Raising awareness for rheumatic mitral valve disease.

Glob Cardiol Sci Pract. 2020;2020(2):e202026 - PMID: 33426043 - PMCID: PMC7768627 - DOI: 10.21542/gcsp.2020.26

Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J

In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves.

JACC Basic Transl Sci. 2020;5(12):1187-1206 - PMID: 33426376 - PMCID: PMC7775962 - DOI: 10.1016/j.jacbts.2020.09.011

Atkins SK, Singh SA, Aikawa E

Calcific Aortic Valve Disease "Omics" Is Timely, But Are We Looking Too Late?

JACC Basic Transl Sci. 2020;5(12):1178-1180 - PMID: 33427821 - PMCID: PMC7775952 - DOI: 10.1016/j.jacbts.2020.11.001