Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital
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Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS
CADASIL mutations impair Notch3 glycosylation by Fringe.
Hum Mol Genet. 2005;14(12):1631-9 - PMID: 15857853 - DOI: 10.1093/hmg/ddi171
Aikawa M, Libby P
Atherosclerotic plaque inflammation: the final frontier?
Can J Cardiol. 2004;20(6):631-4 - PMID: 15152295
Aikawa M
Effects of statin therapy on vascular dysfunction.
Coron Artery Dis. 2004;15(5):227-33 - PMID: 15238817 - DOI: 10.1097/01.mca.0000132583.04711.47
Libby P, Aikawa M
Mechanisms of plaque stabilization with statins.
Am J Cardiol. 2003;91(4A):4B-8B - PMID: 12615292 - DOI: 10.1016/s0002-9149(02)03267-8
Libby P, Aikawa M
New insights into plaque stabilisation by lipid lowering.
Drugs. 1998;56 Suppl 1:9-13; discussion 33 - PMID: 9740536 - DOI: 10.2165/00003495-199856001-00002
Libby P, Mach F, Schönbeck U, Bourcier T, Aikawa M
Regulation of the thrombotic potential of atheroma.
Thromb Haemost. 1999;82(2):736-41 - PMID: 10605776
Aikawa M, Manabe I, Chester A, Aikawa E
Cardiovascular inflammation.
Int J Inflam. 2012;2012:904608 - PMID: 22518345 - PMCID: PMC3317089 - DOI: 10.1155/2012/904608
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109
Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
J Immunol. 2012;189(5):2553-62 - PMID: 22815286 - PMCID: PMC3424398 - DOI: 10.4049/jimmunol.1103606
Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.
Eur Heart J. 2012;34(8):615-24 - PMID: 22927557 - PMCID: PMC3578265 - DOI: 10.1093/eurheartj/ehs271
Zheng C, Aikawa M
High-Density Lipoproteins: From Function to Therapy.
J Am Coll Cardiol. 2012;60(23):2380-3 - PMID: 23141492 - DOI: 10.1016/j.jacc.2012.08.999
Goettsch C, Iwata H, Aikawa E
Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.
Arterioscler Thromb Vasc Biol. 2014;34(7):1333-5 - PMID: 24951650 - PMCID: PMC4094346 - DOI: 10.1161/ATVBAHA.114.303637
Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A
Directing Valvular Interstitial Cell Myofibroblast-Like Differentiation in a Hybrid Hydrogel Platform.
Adv Healthc Mater. 2014;4(1):121-30 - PMID: 24958085 - PMCID: PMC4276556 - DOI: 10.1002/adhm.201400029
Rogers MA, Aikawa E
Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation.
Circ Res. 2014;114(7):1074-6 - PMID: 24677232 - PMCID: PMC3989539 - DOI: 10.1161/CIRCRESAHA.114.303684
Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E
A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program.
PLoS One. 2014;9(3):e89627 - PMID: 24595280 - PMCID: PMC3940696 - DOI: 10.1371/journal.pone.0089627
Hutcheson JD, Aikawa E, Merryman WD
Potential drug targets for calcific aortic valve disease.
Nat Rev Cardiol. 2014;11(4):218-31 - PMID: 24445487 - PMCID: PMC4263317 - DOI: 10.1038/nrcardio.2014.1
Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E
Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis.
Arterioscler Thromb Vasc Biol. 2013;34(3):626-34 - PMID: 24357058 - PMCID: PMC3959796 - DOI: 10.1161/ATVBAHA.113.302576
Rogers M, Goettsch C, Aikawa E
Medial and intimal calcification in chronic kidney disease: stressing the contributions.
J Am Heart Assoc. 2013;2(5):e000481 - PMID: 24060959 - PMCID: PMC3835265 - DOI: 10.1161/JAHA.113.000481
New SE, Aikawa E
Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification.
Arterioscler Thromb Vasc Biol. 2013;33(8):1753-8 - PMID: 23766262 - PMCID: PMC3788633 - DOI: 10.1161/ATVBAHA.112.300128
Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, Weinbaum S
Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries.
Proc Natl Acad Sci U S A. 2013;110(26):10741-6 - PMID: 23733926 - PMCID: PMC3696743 - DOI: 10.1073/pnas.1308814110
Wang JG, Aikawa E, Aikawa M
Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis.
J Am Coll Cardiol. 2013;62(16):1442-5 - PMID: 23707315 - DOI: 10.1016/j.jacc.2013.04.054
Votteler M, Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K
Elastogenesis at the onset of human cardiac valve development.
Development. 2013;140(11):2345-53 - PMID: 23637335 - PMCID: PMC3912871 - DOI: 10.1242/dev.093500
New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E
Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.
Circ Res. 2013;113(1):72-7 - PMID: 23616621 - PMCID: PMC3703850 - DOI: 10.1161/CIRCRESAHA.113.301036
Abe J, Manabe I, Aikawa M, Aikawa E
Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation.
Int J Inflam. 2013;2013:953463 - PMID: 23555068 - PMCID: PMC3608100 - DOI: 10.1155/2013/953463
Goettsch C, Hutcheson JD, Aikawa E
MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.
Circ Res. 2013;112(7):1073-84 - PMID: 23538277 - PMCID: PMC3668680 - DOI: 10.1161/CIRCRESAHA.113.300937
Hjortnaes J, New SE, Aikawa E
Visualizing novel concepts of cardiovascular calcification.
Trends Cardiovasc Med. 2013;23(3):71-9 - PMID: 23290463 - PMCID: PMC3626075 - DOI: 10.1016/j.tcm.2012.09.003
Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation.
PLoS Biol. 2012;10(12):e1001450 - PMID: 23271954 - PMCID: PMC3525526 - DOI: 10.1371/journal.pbio.1001450
Wang J, Lindholt JS, Sukhova GK, Shi MA, Xia M, Chen H, Xiang M, He A, Wang Y, Xiong N, Libby P, Wang JA, Shi GP
IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.
EMBO Mol Med. 2014;6(7):952-69 - PMID: 24963147 - PMCID: PMC4119357 - DOI: 10.15252/emmm.201303811
Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xia M, Xiong N, Gelb BD, Shi GP
Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice.
Arterioscler Thromb Vasc Biol. 2011;32(1):15-23 - PMID: 21817099 - PMCID: PMC3230668 - DOI: 10.1161/ATVBAHA.111.235002
Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP
Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice.
Arterioscler Thromb Vasc Biol. 2011;31(11):2500-8 - PMID: 21868704 - PMCID: PMC3312037 - DOI: 10.1161/ATVBAHA.111.230201
Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP
Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.
Circ Res. 2011;108(11):1316-27 - PMID: 21493897 - PMCID: PMC3108141 - DOI: 10.1161/CIRCRESAHA.111.243758
Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.
Circulation. 2009;120(11):973-82 - PMID: 19720934 - PMCID: PMC2757146 - DOI: 10.1161/CIRCULATIONAHA.109.849679
Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP
Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
Nat Med. 2007;13(6):719-24 - PMID: 17546038 - DOI: 10.1038/nm1601
Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP
Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice.
J Clin Invest. 2007;117(11):3359-68 - PMID: 17932568 - PMCID: PMC2000808 - DOI: 10.1172/JCI31311
Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice.
J Clin Invest. 2011;121(9):3564-77 - PMID: 21821913 - PMCID: PMC3163955 - DOI: 10.1172/JCI46028
Schulte S, Sun J, Libby P, Macfarlane L, Sun C, Lopez-Ilasaca M, Shi GP, Sukhova GK
Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice.
Am J Pathol. 2010;177(1):456-63 - PMID: 20472891 - PMCID: PMC2893687 - DOI: 10.2353/ajpath.2010.090381
Tang EH, Shvartz E, Shimizu K, Rocha VZ, Zheng C, Fukuda D, Shi GP, Sukhova G, Libby P
Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation.
Arterioscler Thromb Vasc Biol. 2010;31(2):261-9 - PMID: 21088251 - PMCID: PMC3025710 - DOI: 10.1161/ATVBAHA.110.216580
Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P
Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms.
Circulation. 1999;99(1):96-104 - PMID: 9884385 - DOI: 10.1161/01.cir.99.1.96
Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA
Cystatin C deficiency in human atherosclerosis and aortic aneurysms.
J Clin Invest. 1999;104(9):1191-7 - PMID: 10545518 - PMCID: PMC409823 - DOI: 10.1172/JCI7709
Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
Nat Med. 2009;15(8):940-5 - PMID: 19633655 - PMCID: PMC2736875 - DOI: 10.1038/nm.1994
Krettek A, Sukhova GK, Libby P
Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis.
Arterioscler Thromb Vasc Biol. 2003;23(4):582-7 - PMID: 12615674 - DOI: 10.1161/01.ATV.0000064372.78561.A5
Schönbeck U, Sukhova GK, Gerdes N, Libby P
T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm.
Am J Pathol. 2002;161(2):499-506 - PMID: 12163375 - PMCID: PMC1850720 - DOI: 10.1016/S0002-9440(10)64206-X
Schulte S, Sukhova GK, Libby P
Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis.
Am J Pathol. 2008;172(6):1500-8 - PMID: 18467709 - PMCID: PMC2408411 - DOI: 10.2353/ajpath.2008.070776
Krettek A, Sukhova GK, Schönbeck U, Libby P
Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells.
Am J Pathol. 2004;165(5):1571-81 - PMID: 15509527 - PMCID: PMC1618684 - DOI: 10.1016/S0002-9440(10)63414-1
Tang EH, Shimizu K, Christen T, Rocha VZ, Shvartz E, Tesmenitsky Y, Sukhova G, Shi GP, Libby P
Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions.
Cardiovasc Res. 2010;89(1):234-43 - PMID: 20736236 - PMCID: PMC3002867 - DOI: 10.1093/cvr/cvq262
Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP
Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.
Circ Res. 2005;96(3):368-75 - PMID: 15653570 - DOI: 10.1161/01.RES.0000155964.34150.F7
Knox JB, Sukhova GK, Whittemore AD, Libby P
Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases.
Circulation. 1997;95(1):205-12 - PMID: 8994438 - DOI: 10.1161/01.cir.95.1.205
Nakagawa T, Sukhova GK, Rabkin E, Winters GL, Schoen FJ, Libby P
Acute rejection accelerates graft coronary disease in transplanted rabbit hearts.
Circulation. 1995;92(4):987-93 - PMID: 7641383 - DOI: 10.1161/01.cir.92.4.987
Sukhova GK, Schönbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P
Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.
Circulation. 1999;99(19):2503-9 - PMID: 10330380 - DOI: 10.1161/01.cir.99.19.2503
Laufs U, Endres M, Stagliano N, Amin-Hanjani S, Chui DS, Yang SX, Simoncini T, Yamada M, Rabkin E, Allen PG, Huang PL, Böhm M, Schoen FJ, Moskowitz MA, Liao JK
Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
J Clin Invest. 2000;106(1):15-24 - PMID: 10880044 - PMCID: PMC314365 - DOI: 10.1172/JCI9639
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