Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital
Sort by:
Reset
Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS
CADASIL mutations impair Notch3 glycosylation by Fringe.
Hum Mol Genet. 2005;14(12):1631-9 - PMID: 15857853 - DOI: 10.1093/hmg/ddi171
Aikawa M, Libby P
Atherosclerotic plaque inflammation: the final frontier?
Can J Cardiol. 2004;20(6):631-4 - PMID: 15152295
Aikawa M
Effects of statin therapy on vascular dysfunction.
Coron Artery Dis. 2004;15(5):227-33 - PMID: 15238817 - DOI: 10.1097/01.mca.0000132583.04711.47
Libby P, Aikawa M
Mechanisms of plaque stabilization with statins.
Am J Cardiol. 2003;91(4A):4B-8B - PMID: 12615292 - DOI: 10.1016/s0002-9149(02)03267-8
Libby P, Aikawa M
New insights into plaque stabilisation by lipid lowering.
Drugs. 1998;56 Suppl 1:9-13; discussion 33 - PMID: 9740536 - DOI: 10.2165/00003495-199856001-00002
Libby P, Mach F, Schönbeck U, Bourcier T, Aikawa M
Regulation of the thrombotic potential of atheroma.
Thromb Haemost. 1999;82(2):736-41 - PMID: 10605776
Aikawa M, Manabe I, Chester A, Aikawa E
Cardiovascular inflammation.
Int J Inflam. 2012;2012:904608 - PMID: 22518345 - PMCID: PMC3317089 - DOI: 10.1155/2012/904608
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proc Natl Acad Sci U S A. 2012;109(27):E1868-77 - PMID: 22699504 - PMCID: PMC3390871 - DOI: 10.1073/pnas.1116889109
Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
J Immunol. 2012;189(5):2553-62 - PMID: 22815286 - PMCID: PMC3424398 - DOI: 10.4049/jimmunol.1103606
Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.
Eur Heart J. 2012;34(8):615-24 - PMID: 22927557 - PMCID: PMC3578265 - DOI: 10.1093/eurheartj/ehs271
Zheng C, Aikawa M
High-Density Lipoproteins: From Function to Therapy.
J Am Coll Cardiol. 2012;60(23):2380-3 - PMID: 23141492 - DOI: 10.1016/j.jacc.2012.08.999
Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation.
PLoS Biol. 2012;10(12):e1001450 - PMID: 23271954 - PMCID: PMC3525526 - DOI: 10.1371/journal.pbio.1001450
Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xia M, Xiong N, Gelb BD, Shi GP
Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice.
Arterioscler Thromb Vasc Biol. 2011;32(1):15-23 - PMID: 21817099 - PMCID: PMC3230668 - DOI: 10.1161/ATVBAHA.111.235002
Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP
Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice.
Arterioscler Thromb Vasc Biol. 2011;31(11):2500-8 - PMID: 21868704 - PMCID: PMC3312037 - DOI: 10.1161/ATVBAHA.111.230201
Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP
Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.
Circ Res. 2011;108(11):1316-27 - PMID: 21493897 - PMCID: PMC3108141 - DOI: 10.1161/CIRCRESAHA.111.243758
Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.
Circulation. 2009;120(11):973-82 - PMID: 19720934 - PMCID: PMC2757146 - DOI: 10.1161/CIRCULATIONAHA.109.849679
Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP
Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
Nat Med. 2007;13(6):719-24 - PMID: 17546038 - DOI: 10.1038/nm1601
Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP
Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice.
J Clin Invest. 2007;117(11):3359-68 - PMID: 17932568 - PMCID: PMC2000808 - DOI: 10.1172/JCI31311
Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice.
J Clin Invest. 2011;121(9):3564-77 - PMID: 21821913 - PMCID: PMC3163955 - DOI: 10.1172/JCI46028
Schulte S, Sun J, Libby P, Macfarlane L, Sun C, Lopez-Ilasaca M, Shi GP, Sukhova GK
Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice.
Am J Pathol. 2010;177(1):456-63 - PMID: 20472891 - PMCID: PMC2893687 - DOI: 10.2353/ajpath.2010.090381
Tang EH, Shvartz E, Shimizu K, Rocha VZ, Zheng C, Fukuda D, Shi GP, Sukhova G, Libby P
Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation.
Arterioscler Thromb Vasc Biol. 2010;31(2):261-9 - PMID: 21088251 - PMCID: PMC3025710 - DOI: 10.1161/ATVBAHA.110.216580
Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P
Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms.
Circulation. 1999;99(1):96-104 - PMID: 9884385 - DOI: 10.1161/01.cir.99.1.96
Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA
Cystatin C deficiency in human atherosclerosis and aortic aneurysms.
J Clin Invest. 1999;104(9):1191-7 - PMID: 10545518 - PMCID: PMC409823 - DOI: 10.1172/JCI7709
Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
Nat Med. 2009;15(8):940-5 - PMID: 19633655 - PMCID: PMC2736875 - DOI: 10.1038/nm.1994
Krettek A, Sukhova GK, Libby P
Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis.
Arterioscler Thromb Vasc Biol. 2003;23(4):582-7 - PMID: 12615674 - DOI: 10.1161/01.ATV.0000064372.78561.A5
Schönbeck U, Sukhova GK, Gerdes N, Libby P
T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm.
Am J Pathol. 2002;161(2):499-506 - PMID: 12163375 - PMCID: PMC1850720 - DOI: 10.1016/S0002-9440(10)64206-X
Schulte S, Sukhova GK, Libby P
Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis.
Am J Pathol. 2008;172(6):1500-8 - PMID: 18467709 - PMCID: PMC2408411 - DOI: 10.2353/ajpath.2008.070776
Krettek A, Sukhova GK, Schönbeck U, Libby P
Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells.
Am J Pathol. 2004;165(5):1571-81 - PMID: 15509527 - PMCID: PMC1618684 - DOI: 10.1016/S0002-9440(10)63414-1
Tang EH, Shimizu K, Christen T, Rocha VZ, Shvartz E, Tesmenitsky Y, Sukhova G, Shi GP, Libby P
Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions.
Cardiovasc Res. 2010;89(1):234-43 - PMID: 20736236 - PMCID: PMC3002867 - DOI: 10.1093/cvr/cvq262
Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP
Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.
Circ Res. 2005;96(3):368-75 - PMID: 15653570 - DOI: 10.1161/01.RES.0000155964.34150.F7
Knox JB, Sukhova GK, Whittemore AD, Libby P
Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases.
Circulation. 1997;95(1):205-12 - PMID: 8994438 - DOI: 10.1161/01.cir.95.1.205
Nakagawa T, Sukhova GK, Rabkin E, Winters GL, Schoen FJ, Libby P
Acute rejection accelerates graft coronary disease in transplanted rabbit hearts.
Circulation. 1995;92(4):987-93 - PMID: 7641383 - DOI: 10.1161/01.cir.92.4.987
Sukhova GK, Schönbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P
Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.
Circulation. 1999;99(19):2503-9 - PMID: 10330380 - DOI: 10.1161/01.cir.99.19.2503
Laufs U, Endres M, Stagliano N, Amin-Hanjani S, Chui DS, Yang SX, Simoncini T, Yamada M, Rabkin E, Allen PG, Huang PL, Böhm M, Schoen FJ, Moskowitz MA, Liao JK
Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
J Clin Invest. 2000;106(1):15-24 - PMID: 10880044 - PMCID: PMC314365 - DOI: 10.1172/JCI9639
Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE
Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo.
Nat Med. 2001;7(9):1035-40 - PMID: 11533707 - PMCID: PMC2818999 - DOI: 10.1038/nm0901-1035
Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J
Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro.
Am J Pathol. 2001;159(4):1335-43 - PMID: 11583961 - PMCID: PMC1850524 - DOI: 10.1016/s0002-9440(10)62520-5
Rabkin E, Hoerstrup SP, Aikawa M, Mayer JE, Schoen FJ
Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling.
J Heart Valve Dis. 2002;11(3):308-14; discussion 314 - PMID: 12056720
Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J
NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.
J Biol Chem. 2002;278(3):1686-92 - PMID: 12427739 - PMCID: PMC2813494 - DOI: 10.1074/jbc.M210250200
Simoncini T, Rabkin E, Liao JK
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
Arterioscler Thromb Vasc Biol. 2003;23(2):198-203 - PMID: 12588759 - DOI: 10.1161/01.atv.0000053846.71621.93
Engelmayr GC, Rabkin E, Sutherland FW, Schoen FJ, Mayer JE, Sacks MS
The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue.
Biomaterials. 2005;26(2):175-87 - PMID: 15207464 - DOI: 10.1016/j.biomaterials.2004.02.035
Wu X, Rabkin-Aikawa E, Guleserian KJ, Perry TE, Masuda Y, Sutherland FW, Schoen FJ, Mayer JE, Bischoff J
Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells.
Am J Physiol Heart Circ Physiol. 2004;287(2):H480-7 - PMID: 15277191 - DOI: 10.1152/ajpheart.01232.2003
Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ
Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.
J Thorac Cardiovasc Surg. 2004;128(4):552-61 - PMID: 15457156 - DOI: 10.1016/j.jtcvs.2004.04.016
Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ
Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.
J Heart Valve Dis. 2004;13(5):841-7 - PMID: 15473488
Sutherland FW, Perry TE, Yu Y, Sherwood MC, Rabkin E, Masuda Y, Garcia GA, McLellan DL, Engelmayr GC, Sacks MS, Schoen FJ, Mayer JE
From stem cells to viable autologous semilunar heart valve.
Circulation. 2005;111(21):2783-91 - PMID: 15927990 - DOI: 10.1161/CIRCULATIONAHA.104.498378
Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation. 2005;112(4):578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616
Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
Circulation. 2005;112(15):2324-31 - PMID: 16203910 - DOI: 10.1161/CIRCULATIONAHA.105.538942
Yamada S, Yoshida H, Taniguchi M, Tanaka S, Eriguchi M, Nakano T, Tsuruya K, Kitazono T
Effectiveness of lanthanum carbonate treatment used in combination with other phosphate binders in peritoneal dialysis patients.
Intern Med. 2012;51(16):2097-104 - PMID: 22892485 - DOI: 10.2169/internalmedicine.51.6814
Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, Tsuruya K, Iida M, Kiyohara Y, Sueishi K
Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study.
Am J Kidney Dis. 2009;55(1):21-30 - PMID: 19765871 - DOI: 10.1053/j.ajkd.2009.06.034
Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y
A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.
Nat Genet. 2007;39(2):212-7 - PMID: 17206144 - DOI: 10.1038/ng1945
Eriguchi M, Tsuruya K, Yoshida H, Yamada S, Tanaka S, Suehiro T, Nakano T, Taniguchi M
Validation of the exit-site scoring system recommended by the 2005 guidelines of the International Society for Peritoneal Dialysis.
Perit Dial Int. 2011;31(6):698-700 - PMID: 22123857 - DOI: 10.3747/pdi.2010.00287
179