Aikawa-Aikawa Laboratories

Matamalas JT, Chelvanambi S, Decano JL, França RF, Halu A, Santinelli-Pestana DV, Aikawa E, Malhotra R, Aikawa M

Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals.

PNAS Nexus. 2024;3(8):pgae294 - PMID: 39192848 - PMCID: PMC11348562 - DOI: 10.1093/pnasnexus/pgae294

Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Wei W, Aikawa M, Shi J, Chen H

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing.

bioRxiv. 2024;:ePub - PMID: 39253510 - PMCID: PMC11383039 - DOI: 10.1101/2024.02.07.579019

Peng Q, Arulsamy K, Lu YW, Wu H, Zhu B, Singh B, Cui K, Wylie-Sears J, Li K, Wong S, Cowan DB, Aikawa M, Wang DZ, Bischoff J, Chen K, Chen H

Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis.

bioRxiv. 2024;:ePub - PMID: 39282400 - PMCID: PMC11398423 - DOI: 10.1101/2024.09.03.610974

Yagi H, Boeck M, Petrishka-Lozenska M, Lundgren P, Kasai T, Cagnone G, Neilsen K, Wang C, Lee J, Tomita Y, Singh SA, Joyal JS, Aikawa M, Negishi K, Fu Z, Hellström A, Smith LEH

Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity.

Angiogenesis. 2024;:ePub - PMID: 39287727 - DOI: 10.1007/s10456-024-09948-2

Garelnabi M, Ntsekhe M, Doubell A, Aikawa M

Editorial: Global Excellence in Cardiovascular Medicine in Africa: challenges and opportunities.

Front Cardiovasc Med. 2024;11:1479281 - PMID: 39502195 - PMCID: PMC11534761 - DOI: 10.3389/fcvm.2024.1479281

Iwata A, Chelvanambi S, Asano T, Whelan M, Nakamura Y, Aikawa E, Sasaki Y, Aikawa M

Gene expression profiles of precursor cells identify compounds that reduce NRP1 surface expression in macrophages: Implication for drug repositioning for COVID-19.

Front Cardiovasc Med. 2024;11:1438396 - PMID: 39512370 - PMCID: PMC11541348 - DOI: 10.3389/fcvm.2024.1438396

Kip P, Sluiter TJ, MacArthur MR, Tao M, Kruit N, Mitchell SJ, Jung J, Kooijman S, Gorham J, Seidman JG, Quax PHA, Decano JL, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR

Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice.

Nat Commun. 2024;15(1):9652 - PMID: 39511181 - DOI: 10.1038/s41467-024-53844-8

Kasai T, Nakamura Y, Aikawa M, Singh SA

In-Source Collision-Induced Dissociation (CID) Improves Higher-Energy Collisional Dissociation (HCD)-Dependent Fragmentation of ADP-Ribosyl Peptides.

Rapid Commun Mass Spectrom. 2025;39(4):e9961 - PMID: 39632390 - DOI: 10.1002/rcm.9961

Villa-Roel N, Park C, Andueza A, Baek KI, Su A, Blaser MC, Leshnower BG, Yoganathan A, Aikawa E, Jo H

Side- and Disease-Dependent Changes in Human Aortic Valve Cell Population and Transcriptomic Heterogeneity Determined by Single-Cell RNA Sequencing.

Genes (Basel). 2024;15(12):ePub - PMID: 39766890 - PMCID: PMC11675841 - DOI: 10.3390/genes15121623

Costa de Freitas RC, Bortolin RH, Kuraoka S, Rogers MA, Blaser MC, Chelvanambi S, Borges JB, de Oliveira VF, Dagli-Hernandez C, Bastos GM, da Silva Rodrigues Marçal E, Malaquias VB, Gonçalves RM, Faludi AA, Silbiger VN, Luchessi AD, Aikawa M, Crespo Hirata RD, Singh SA, Aikawa E, Hirata MH

Integrative analysis of miRNAs and proteins in plasma extracellular vesicles of patients with familial hypercholesterolemia.

Clin Chim Acta. 2025;:120123 - PMID: 39778611 - DOI: 10.1016/j.cca.2025.120123

Halu A, Chelvanambi S, Decano JL, Matamalas JT, Whelan M, Asano T, Kalicharran N, Singh SA, Loscalzo J, Aikawa M

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery.

Genome Med. 2025;17(1):7 - PMID: 39833831 - DOI: 10.1186/s13073-025-01431-x

Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.

JACC Adv. 2025;:101059 - PMID: 39966045 - DOI: 10.1016/j.jacadv.2024.101059

Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.

Circ Cardiovasc Qual Outcomes. 2025;:e000128 - PMID: 39957624 - DOI: 10.1161/HCQ.0000000000000128

Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM

The first International Consortium for Health Outcomes Measurement (ICHOM) standard dataset for reporting outcomes in heart valve disease: moving from device- to patient- centered outcomes.

Eur Heart J Qual Care Clin Outcomes. 2025;:ePub - PMID: 39957667 - DOI: 10.1093/ehjqcco/qcae051

Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Rafael Sádaba J, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.

Eur J Cardiothorac Surg. 2025;67(2):ePub - PMID: 39957685 - PMCID: PMC11842054 - DOI: 10.1093/ejcts/ezae254

Boucher DM, Robichaud S, Lorant V, Leon JS, Suliman I, Rasheed A, Susser LI, Emerton C, Geoffrion M, De Jong E, Bowdish DME, Aikawa M, Aikawa E, Singh SA, Rayner KJ, Ouimet M

Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression.

Arterioscler Thromb Vasc Biol. 2025;:ePub - PMID: 39945065 - DOI: 10.1161/ATVBAHA.124.321662

Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Huang W, Wei W, Aikawa M, Shi J, Chen H

Endothelial FOXM1 and Dab2 promote diabetic wound healing.

JCI Insight. 2025;10(2):ePub - PMID: 39846251 - PMCID: PMC11790024 - DOI: 10.1172/jci.insight.186504

Lansac E, Veen KM, Joseph A, Blancarte Jaber P, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes.

Innovations (Phila). 2025;:15569845241269309 - PMID: 39968696 - DOI: 10.1177/15569845241269309

Boeck M, Yagi H, Chen CT, Zeng Y, Lee D, Nian S, Kasai T, Lee J, Hirst V, Wang C, Neilsen K, Rodrick TC, McCutcheon A, Yu M, Lodhi IJ, Singh SA, Aikawa M, Bazinet RP, Fu Z

Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation.

J Adv Res. 2025;:ePub - PMID: 40049514 - DOI: 10.1016/j.jare.2025.03.004

Lansac E, Veen KM, Joseph A, Jaber PB, Sossi F, Das-Gupta Z, Aktaa S, Sádaba JR, Thourani VH, Dahle G, Szeto WY, Bakaeen F, Aikawa E, Schoen FJ, Girdauskas E, Almeida A, Zuckermann A, Meuris B, Stott J, Kluin J, Meel R, Woan W, Colgan D, Jneid H, Balkhy H, Szerlip M, Preventza O, Shah P, Rigolin VH, Medica S, Holmes P, Sitges M, Pibarot P, Donal E, Hahn RT, Takkenberg JJM

The First International Consortium for Health Outcomes Measurement (ICHOM) Standard Dataset for Reporting Outcomes in Heart Valve Disease: Moving From Device- to Patient-Centered Outcomes: Developed by a multisociety taskforce coordinated by the Heart Valve Society (HVS) including the American Heart Association (AHA), the American College of Cardiology (ACC), the European Association for Cardio-Thoracic Surgery (EACTS), the European Society of Cardiology (ESC), The Society of Thoracic Surgeons (STS), the Australian & New Zealand Society of Cardiac & Thoracic Surgeons (ANZSCTS), the International Society for Applied Cardiovascular Biology (ISACB), the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS), the South African Heart Association (SHA), Heart Valve Voice, and Global Heart Hub.

Ann Thorac Surg Short Rep. 2025;3(1):71-85 - PMID: 40098847 - PMCID: PMC11910787 - DOI: 10.1016/j.atssr.2024.05.005

Song N, Ji E, Yu JE, Choi KH, Kim DH, Song JM, Kang DH, Song JK, Yu J, Kim K, Lee S, Aikawa E

Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification: Implications for DNA Methyltransferase-1 Activity.

JACC Basic Transl Sci. 2025;10(3):345-366 - PMID: 40139876 - DOI: 10.1016/j.jacbts.2024.11.011

Lupieri A, Jha PK, Nizet V, Dutra WO, Nunes MCP, Levine RA, Aikawa E

Rheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder.

Front Cardiovasc Med. 2025;12:1537104 - PMID: 40182432 - PMCID: PMC11966398 - DOI: 10.3389/fcvm.2025.1537104

Jha PK, Nakano T, Itto LYU, Barbeiro MC, Lupieri A, Aikawa E, Aikawa M

Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation.

Front Cardiovasc Med. 2025;12:1574489 - PMID: 40201789 - PMCID: PMC11975941 - DOI: 10.3389/fcvm.2025.1574489