Aikawa-Aikawa Laboratories

Cardiovascular Division, Brigham and Women's Hospital
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Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE
Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo.
Nat Med. 2001;7(9):1035-40 - PMID: 11533707 - PMCID: PMC2818999 - DOI: 10.1038/nm0901-1035
Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J
Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro.
Am J Pathol. 2001;159(4):1335-43 - PMID: 11583961 - PMCID: PMC1850524 - DOI: 10.1016/s0002-9440(10)62520-5
Rabkin E, Hoerstrup SP, Aikawa M, Mayer JE, Schoen FJ
Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling.
J Heart Valve Dis. 2002;11(3):308-14; discussion 314 - PMID: 12056720
Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J
NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.
J Biol Chem. 2002;278(3):1686-92 - PMID: 12427739 - PMCID: PMC2813494 - DOI: 10.1074/jbc.M210250200
Simoncini T, Rabkin E, Liao JK
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
Arterioscler Thromb Vasc Biol. 2003;23(2):198-203 - PMID: 12588759 - DOI: 10.1161/01.atv.0000053846.71621.93
Engelmayr GC, Rabkin E, Sutherland FW, Schoen FJ, Mayer JE, Sacks MS
The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue.
Biomaterials. 2005;26(2):175-87 - PMID: 15207464 - DOI: 10.1016/j.biomaterials.2004.02.035
Wu X, Rabkin-Aikawa E, Guleserian KJ, Perry TE, Masuda Y, Sutherland FW, Schoen FJ, Mayer JE, Bischoff J
Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells.
Am J Physiol Heart Circ Physiol. 2004;287(2):H480-7 - PMID: 15277191 - DOI: 10.1152/ajpheart.01232.2003
Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ
Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.
J Thorac Cardiovasc Surg. 2004;128(4):552-61 - PMID: 15457156 - DOI: 10.1016/j.jtcvs.2004.04.016
Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ
Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.
J Heart Valve Dis. 2004;13(5):841-7 - PMID: 15473488
Sutherland FW, Perry TE, Yu Y, Sherwood MC, Rabkin E, Masuda Y, Garcia GA, McLellan DL, Engelmayr GC, Sacks MS, Schoen FJ, Mayer JE
From stem cells to viable autologous semilunar heart valve.
Circulation. 2005;111(21):2783-91 - PMID: 15927990 - DOI: 10.1161/CIRCULATIONAHA.104.498378
Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation. 2005;112(4):578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616
Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging.
Circulation. 2005;112(15):2324-31 - PMID: 16203910 - DOI: 10.1161/CIRCULATIONAHA.105.538942
Koga J, Aikawa M
Application of anti-ligand antibodies to inhibit notch signaling.
Methods Mol Biol. 2014;1187:335-42 - PMID: 25053501 - DOI: 10.1007/978-1-4939-1139-4_25
Fujisaki K, Tsuruya K, Nakano T, Taniguchi M, Higashi H, Katafuchi R, Kanai H, Nakayama M, Hirakata H, Kitazono T
Impact of combined losartan/hydrochlorothiazide on proteinuria in patients with chronic kidney disease and hypertension.
Hypertens Res. 2014;37(11):993-8 - PMID: 24965167 - DOI: 10.1038/hr.2014.110
Yamada S, Tsuruya K, Taniguchi M, Yoshida H, Tokumoto M, Hasegawa S, Tanaka S, Eriguchi M, Nakano T, Kitazono T
Relationship Between Residual Renal Function and Serum Fibroblast Growth Factor 23 in Patients on Peritoneal Dialysis.
Ther Apher Dial. 2014;18(5):383-90 - PMID: 24674095 - DOI: 10.1111/1744-9987.12170
Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y
Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study.
Kidney Int. 2013;84(2):373-80 - PMID: 23594677 - DOI: 10.1038/ki.2013.111
Yamada S, Tokumoto M, Tatsumoto N, Taniguchi M, Noguchi H, Nakano T, Masutani K, Ooboshi H, Tsuruya K, Kitazono T
Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia.
Am J Physiol Renal Physiol. 2014;306(12):F1418-28 - PMID: 24808541 - DOI: 10.1152/ajprenal.00633.2013
Yamada S, Yoshida H, Taniguchi M, Tanaka S, Eriguchi M, Nakano T, Tsuruya K, Kitazono T
Effectiveness of lanthanum carbonate treatment used in combination with other phosphate binders in peritoneal dialysis patients.
Intern Med. 2012;51(16):2097-104 - PMID: 22892485 - DOI: 10.2169/internalmedicine.51.6814
Fujisaki K, Tsuruya K, Yamato M, Toyonaga J, Noguchi H, Nakano T, Taniguchi M, Tokumoto M, Hirakata H, Kitazono T
Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol.
Nephrol Dial Transplant. 2013;29(3):529-38 - PMID: 24030834 - DOI: 10.1093/ndt/gft327
Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, Tsuruya K, Iida M, Kiyohara Y, Sueishi K
Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study.
Am J Kidney Dis. 2009;55(1):21-30 - PMID: 19765871 - DOI: 10.1053/j.ajkd.2009.06.034
Yamada S, Tsuruya K, Yoshida H, Taniguchi M, Haruyama N, Tanaka S, Eriguchi M, Nakano T, Kitazono T
The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis.
Clin Endocrinol (Oxf). 2013;78(6):844-51 - PMID: 23078546 - DOI: 10.1111/cen.12070
Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y
A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.
Nat Genet. 2007;39(2):212-7 - PMID: 17206144 - DOI: 10.1038/ng1945
Eriguchi M, Tsuruya K, Yoshida H, Yamada S, Tanaka S, Suehiro T, Nakano T, Taniguchi M
Validation of the exit-site scoring system recommended by the 2005 guidelines of the International Society for Peritoneal Dialysis.
Perit Dial Int. 2011;31(6):698-700 - PMID: 22123857 - DOI: 10.3747/pdi.2010.00287
Matsuura M, Onimaru M, Yonemitsu Y, Suzuki H, Nakano T, Ishibashi H, Shirasuna K, Sueishi K
Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells.
Am J Pathol. 2009;175(4):1709-21 - PMID: 19779139 - PMCID: PMC2751566 - DOI: 10.2353/ajpath.2009.081139
Onimaru M, Yonemitsu Y, Fujii T, Tanii M, Nakano T, Nakagawa K, Kohno R, Hasegawa M, Nishikawa S, Sueishi K
VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B.
Am J Physiol Heart Circ Physiol. 2009;297(5):H1685-96 - PMID: 19734356 - DOI: 10.1152/ajpheart.00015.2009
Ikeda Y, Yonemitsu Y, Onimaru M, Nakano T, Miyazaki M, Kohno R, Nakagawa K, Ueno A, Sueishi K, Ishibashi T
The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium.
Exp Eye Res. 2006;83(5):1031-40 - PMID: 16842779 - DOI: 10.1016/j.exer.2006.05.007
Aishima M, Tomoda T, Yunoki T, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N
Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.
Br J Pharmacol. 2006;149(5):542-50 - PMID: 17016513 - PMCID: PMC2014675 - DOI: 10.1038/sj.bjp.0706893
Fujii T, Yonemitsu Y, Onimaru M, Tanii M, Nakano T, Egashira K, Takehara T, Inoue M, Hasegawa M, Kuwano H, Sueishi K
Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway.
Arterioscler Thromb Vasc Biol. 2006;26(11):2483-9 - PMID: 16960104 - DOI: 10.1161/01.ATV.0000244684.23499.bf
Tomoda T, Aishima M, Takano N, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N
The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder.
Br J Pharmacol. 2005;146(1):25-32 - PMID: 15965499 - PMCID: PMC1576239 - DOI: 10.1038/sj.bjp.0706284
Shikada Y, Yonemitsu Y, Koga T, Onimaru M, Nakano T, Okano S, Sata S, Nakagawa K, Yoshino I, Maehara Y, Sueishi K
Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas.
Cancer Res. 2005;65(16):7241-8 - PMID: 16103075 - DOI: 10.1158/0008-5472.CAN-04-4171
Baba H, Yonemitsu Y, Nakano T, Onimaru M, Miyazaki M, Ikeda Y, Sumiyoshi S, Ueda Y, Hasegawa M, Yoshino I, Maehara Y, Sueishi K
Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques.
Arterioscler Thromb Vasc Biol. 2005;25(9):1938-44 - PMID: 15994443 - DOI: 10.1161/01.ATV.0000175759.78338.1e
Nakano T, Nakashima Y, Yonemitsu Y, Sumiyoshi S, Chen YX, Akishima Y, Ishii T, Iida M, Sueishi K
Angiogenesis and lymphangiogenesis and expression of lymphangiogenic factors in the atherosclerotic intima of human coronary arteries.
Hum Pathol. 2005;36(4):330-40 - PMID: 15891993 - DOI: 10.1016/j.humpath.2005.01.001
Fetter-Pruneda I, Geovannini-Acuña H, Santiago C, Ibarrarán-Viniegra AS, Martínez-Martínez E, Sandoval-Velasco M, Uribe-Figueroa L, Padilla-Cortés P, Mercado-Célis G, Gutiérrez-Ospina G
Shifts in developmental timing, and not increased levels of experience-dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth.
PLoS One. 2013;8(1):e54940 - PMID: 23372796 - PMCID: PMC3556040 - DOI: 10.1371/journal.pone.0054940
Martínez-Martínez E, Zaragoza ML, Solano E, Figueroa B, Zúñiga P, Laclette JP
Health research funding in Mexico: the need for a long-term agenda.
PLoS One. 2012;7(12):e51195 - PMID: 23251451 - PMCID: PMC3519634 - DOI: 10.1371/journal.pone.0051195
Martínez-Martínez E, Galván-Hernández CI, Toscano-Márquez B, Gutiérrez-Ospina G
Modulatory role of sensory innervation on hair follicle stem cell progeny during wound healing of the rat skin.
PLoS One. 2012;7(5):e36421 - PMID: 22574159 - PMCID: PMC3344885 - DOI: 10.1371/journal.pone.0036421
Martínez-Martínez E, Toscano-Márquez B, Gutiérrez-Ospina G
Long-term effects of neonatal capsaicin treatment on intraepidermal nerve fibers and keratinocyte proliferation in rat glabrous skin.
Anat Rec (Hoboken). 2010;294(1):173-84 - PMID: 21157928 - DOI: 10.1002/ar.21237
Toscano-Márquez B, Martínez-Martínez E, Manjarrez E, Martínez L, Mendoza-Torreblanca J, Gutiérrez-Ospina G
Late onset muscle plasticity in the whisker pad of enucleated rats.
Proc Natl Acad Sci U S A. 2008;105(41):15973-8 - PMID: 18838691 - PMCID: PMC2572979 - DOI: 10.1073/pnas.0808431105
Mendoza-Torreblanca JG, Martínez-Martínez E, Tapia-Rodríguez M, Ramírez-Hernández R, Gutiérrez-Ospina G
The rostral migratory stream is a neurogenic niche that predominantly engenders periglomerular cells: in vivo evidence in the adult rat brain.
Neurosci Res. 2007;60(3):289-99 - PMID: 18243385 - DOI: 10.1016/j.neures.2007.11.013
Uribe-Querol E, Martínez-Martínez E, Tapia-Rodríguez M, Hernández LR, Toscano-Márquez B, Padilla P, Gutiérrez-Ospina G
Metabolic indices shift in the hypothalamic-neurohypophysial system during lactation: implications for interpreting their relationship with neuronal activity.
Neuroscience. 2005;134(4):1217-22 - PMID: 16054766 - DOI: 10.1016/j.neuroscience.2005.05.059
Mendoza-Milla C, Machuca Rodríguez C, Córdova Alarcón E, Estrada Bernal A, Toledo-Cuevas EM, Martínez Martínez E, Zentella Dehesa A
NF-kappaB activation but not PI3K/Akt is required for dexamethasone dependent protection against TNF-alpha cytotoxicity in L929 cells.
FEBS Lett. 2005;579(18):3947-52 - PMID: 16000198 - DOI: 10.1016/j.febslet.2005.05.081
Zomosa-Signoret V, Hernández-Alcántara G, Reyes-Vivas H, Martínez-Martínez E, Garza-Ramos G, Pérez-Montfort R, Tuena De Gómez-Puyou M, Gómez-Puyou A
Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers.
Biochemistry. 2003;42(11):3311-8 - PMID: 12641463 - DOI: 10.1021/bi0206560
Reyes-Vivas H, Martínez-Martínez E, Mendoza-Hernández G, López-Velázquez G, Pérez-Montfort R, Tuena de Gómez-Puyou M, Gómez-Puyou A
Susceptibility to proteolysis of triosephosphate isomerase from two pathogenic parasites: characterization of an enzyme with an intact and a nicked monomer.
Proteins. 2002;48(3):580-90 - PMID: 12112681 - DOI: 10.1002/prot.10179
Nagy E, Janszky I, Eriksson-Berg M, Al-Khalili F, Schenck-Gustafsson K
The effects of exercise capacity and sedentary lifestyle on haemostasis among middle-aged women with coronary heart disease.
Thromb Haemost. 2008;100(5):899-904 - PMID: 18989536 - DOI: 10.1160/th07-10-0650
Nagy E, Andersson DC, Caidahl K, Eriksson MJ, Eriksson P, Franco-Cereceda A, Hansson GK, Bäck M
Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts.
Circulation. 2011;123(12):1316-25 - PMID: 21403093 - DOI: 10.1161/CIRCULATIONAHA.110.966846
Nagy E, Caidahl K, Franco-Cereceda A, Bäck M
Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity.
Biochem Biophys Res Commun. 2012;420(3):671-5 - PMID: 22450322 - DOI: 10.1016/j.bbrc.2012.03.064
Nagy E, Bäck M
Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis.
FEBS Lett. 2012;586(9):1325-9 - PMID: 22616993 - DOI: 10.1016/j.febslet.2012.03.039
Eaton A, Nagy E, Pacault M, Fauconnier J, Bäck M
Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.
J Mol Med (Berl). 2012;90(10):1223-31 - PMID: 22527886 - PMCID: PMC3438394 - DOI: 10.1007/s00109-012-0904-1
Bäck M, Yin L, Nagy E, Ingelsson E
The leukotriene receptor antagonist montelukast and aortic stenosis.
Br J Clin Pharmacol. 2013;75(1):280-1 - PMID: 22616719 - PMCID: PMC3555071 - DOI: 10.1111/j.1365-2125.2012.04338.x
Jensen AS, Johansson PI, Idorn L, Sørensen KE, Thilén U, Nagy E, Furenäs E, Søndergaard L
The haematocrit--an important factor causing impaired haemostasis in patients with cyanotic congenital heart disease.
Int J Cardiol. 2012;167(4):1317-21 - PMID: 22578951 - DOI: 10.1016/j.ijcard.2012.03.181
Jensen AS, Johansson PI, Bochsen L, Idorn L, Sørensen KE, Thilén U, Nagy E, Furenäs E, Søndergaard L
Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease.
Int J Cardiol. 2012;167(5):2210-4 - PMID: 22727966 - DOI: 10.1016/j.ijcard.2012.06.019
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