Aikawa-Aikawa Laboratories

Collste O, Sörensson P, Frick M, Agewall S, Daniel M, Henareh L, Ekenbäck C, Eurenius L, Guiron C, Jernberg T, Hofman-Bang C, Malmqvist K, Nagy E, Arheden H, Tornvall P

Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging: results from the Stockholm Myocardial Infarction with Normal Coronaries study.

J Intern Med. 2012;273(2):189-96 - PMID: 22742529 - DOI: 10.1111/j.1365-2796.2012.02567.x

Nagy E, Eriksson P, Yousry M, Caidahl K, Ingelsson E, Hansson GK, Franco-Cereceda A, Bäck M

Valvular osteoclasts in calcification and aortic valve stenosis severity.

Int J Cardiol. 2013;168(3):2264-71 - PMID: 23452891 - DOI: 10.1016/j.ijcard.2013.01.207

Jensen AS, Johansson PI, Bochsen L, Idorn L, Sørensen KE, Thilén U, Nagy E, Furenäs E, Søndergaard L

Response letter to: "hypocoagulable" thromboelastography profiles in patients with cyanotic congenital heart disease: facts or technical artifacts?

Int J Cardiol. 2013;168(4):4426 - PMID: 23706329 - DOI: 10.1016/j.ijcard.2013.05.009

Labat C, Temmar M, Nagy E, Bean K, Brink C, Benetos A, Bäck M

Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis.

J Hypertens. 2013;31(11):2251-8; discussion 2258 - PMID: 23868086 - PMCID: PMC3819311 - DOI: 10.1097/HJH.0b013e328363dccc

Hutcheson JD, Maldonado N, Aikawa E

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.

Curr Opin Lipidol. 2014;25(5):327-32 - PMID: 25188916 - PMCID: PMC4166045 - DOI: 10.1097/MOL.0000000000000105

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E

Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease.

Arterioscler Thromb Vasc Biol. 2014;34(11):2387-93 - PMID: 25189570 - PMCID: PMC4199903 - DOI: 10.1161/ATVBAHA.114.302523

Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E

Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.

J Extracell Vesicles. 2014;3:25129 - PMID: 25491249 - PMCID: PMC4261240 - DOI: 10.3402/jev.v3.25129

Fujita R, Tamai K, Aikawa E, Nimura K, Ishino S, Kikuchi Y, Kaneda Y

Endogenous Mesenchymal Stromal Cells in Bone Marrow are Required to Preserve Muscle Function in Mdx Mice.

Stem Cells. 2014;33(3):962-75 - PMID: 25408548 - DOI: 10.1002/stem.1900

Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, St?pie? E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS

EVpedia: a community web portal for extracellular vesicles research.

Bioinformatics. 2014;31(6):933-9 - PMID: 25388151 - PMCID: PMC4375401 - DOI: 10.1093/bioinformatics/btu741

Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E

Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.

Am J Pathol. 2015;185(4):1156-66 - PMID: 25680278 - PMCID: PMC4380840 - DOI: 10.1016/j.ajpath.2014.11.026

Ruiz JL, Hutcheson JD, Aikawa E

Cardiovascular calcification: current controversies and novel concepts.

Cardiovasc Pathol. 2015;24(4):207-12 - PMID: 25797772 - DOI: 10.1016/j.carpath.2015.03.002

Lu H, Aikawa M

Many faces of matrix metalloproteinases in aortic aneurysms.

Arterioscler Thromb Vasc Biol. 2015;35(4):752-4 - PMID: 25810296 - DOI: 10.1161/ATVBAHA.115.305401

Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E

N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification

J. Cardiovasc. Dev. Dis. 2015;2(2):31-47 - PMID: 29371511 - PMCID: PMC5753093 - DOI: 10.3390/jcdd2020031

Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M

New CETP Inhibitor K-312 Reduces PCSK9 Expression: A Potential Effect on LDL Cholesterol Metabolism.

Am J Physiol Endocrinol Metab. 2015;309(2):E177-90 - PMID: 26015437 - DOI: 10.1152/ajpendo.00528.2014

Salinas M, Schmidt DE, Libera M, Lange RR, Ramaswamy S

Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations.

Comput Methods Biomech Biomed Engin. 2012;17(7):728-39 - PMID: 22920330 - DOI: 10.1080/10255842.2012.715157

Salinas M, Schmidt DE, Libera M, Lange RR, Ramaswamy S

Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations.

Comput Methods Biomech Biomed Engin. 2012;17(7):728-39 - PMID: 22920330 - DOI: 10.1080/10255842.2012.715157

Aikawa E, Fujita R, Kikuchi Y, Kaneda Y, Tamai K

Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFR?(+) mesenchymal cells from bone marrow.

Sci Rep. 2015;5:11008 - PMID: 26046579 - PMCID: PMC4457135 - DOI: 10.1038/srep11008

Aikawa E, Gardiner C, Hutcheson JD, Ochiya T, Osteikoetxea X, Pegtel M, Piper M, Quesenberry P, Schiffelers RM, Szabó TG, Buzas EI

International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013).

J Extracell Vesicles. 2013;2:23070 - PMID: 26082318 - PMCID: PMC3854124 - DOI: 10.3402/jev.v2i0.23070

Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.

PLoS One. 2015;10(7):e0131176 - PMID: 26132105 - PMCID: PMC4489192 - DOI: 10.1371/journal.pone.0131176

Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E

Valvular interstitial cells suppress calcification of valvular endothelial cells.

Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848 - DOI: 10.1016/j.atherosclerosis.2015.07.008

Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA

mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.

J Proteomics. 2015;128:132-40 - PMID: 26232111 - DOI: 10.1016/j.jprot.2015.07.024

Rogers MA, Aikawa E

A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.

Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561 - DOI: 10.1161/CIRCULATIONAHA.115.018139

Singh SA, Miyosawa K, Aikawa M

Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.

Expert Rev Proteomics. 2015;12(5):519-32 - PMID: 26325144 - DOI: 10.1586/14789450.2015.1078731

Hutcheson JD, Goettsch C, Rogers MA, Aikawa E

Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach.

Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815 - DOI: 10.1016/j.semcdb.2015.09.004

Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.

PLoS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429 - DOI: 10.1371/journal.pone.0138047

Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.

Arterioscler Thromb Vasc Biol. 2015;35(11):2343-2353 - PMID: 26404485 - PMCID: PMC5003117 - DOI: 10.1161/ATVBAHA.115.305516

Wang JG, Aikawa M

Toll-Like Receptors and Src-Family Kinases in Atherosclerosis?- Focus on Macrophages.

Circ J. 2015;79(11):2332-4 - PMID: 26467082 - DOI: 10.1253/circj.CJ-15-1039

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,

Mitral valve disease-morphology and mechanisms.

Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623 - DOI: 10.1038/nrcardio.2015.161

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB

Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.

J Biol Chem. 2015;291(3):1115-22 - PMID: 26511317 - PMCID: PMC4714195 - DOI: 10.1074/jbc.M115.668269

Katsuki S, Matoba T, Nakashiro S, Sato K, Koga J, Nakano K, Nakano Y, Egusa S, Sunagawa K, Egashira K

Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes.

Circulation. 2013;129(8):896-906 - PMID: 24305567 - DOI: 10.1161/CIRCULATIONAHA.113.002870

Sato K, Nakano K, Katsuki S, Matoba T, Osada K, Sawamura T, Sunagawa K, Egashira K

Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.

J Atheroscler Thromb. 2012;19(11):986-98 - PMID: 22785139 - DOI: 10.5551/jat.13391

Katsuki S, Matoba T, Nakashiro S, Sato K, Koga J, Nakano K, Nakano Y, Egusa S, Sunagawa K, Egashira K

Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes.

Circulation. 2013;129(8):896-906 - PMID: 24305567 - DOI: 10.1161/CIRCULATIONAHA.113.002870

Fiuza JA, Gannavaram S, Santiago Hda C, Selvapandiyan A, Souza DM, Passos LS, de Mendonça LZ, Lemos-Giunchetti Dda S, Ricci ND, Bartholomeu DC, Giunchetti RC, Bueno LL, Correa-Oliveira R, Nakhasi HL, Fujiwara RT

Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum.

Vaccine. 2014;33(2):280-8 - PMID: 25475955 - DOI: 10.1016/j.vaccine.2014.11.039

Hojo-Souza NS, Pereira DB, Mendes TA, Passos LS, Gazzinelli-Guimarães AC, Gazzinelli-Guimarães PH, Tada MS, Zanini GM, Bartholomeu DC, Fujiwara RT, Bueno LL

CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways.

Malar J. 2015;14:5 - PMID: 25559491 - PMCID: PMC4326293 - DOI: 10.1186/1475-2875-14-5

Hojo-Souza NS, Pereira DB, Passos LS, Gazzinelli-Guimarães PH, Cardoso MS, Tada MS, Zanini GM, Bartholomeu DC, Fujiwara RT, Bueno LL

Phenotypic profiling of CD8(+) T cells during Plasmodium vivax blood-stage infection.

BMC Infect Dis. 2015;15:35 - PMID: 25636730 - PMCID: PMC4329216 - DOI: 10.1186/s12879-015-0762-x

Gazzinelli-Guimarães PH, Gazzinelli-Guimarães AC, Silva FN, Mati VL, Dhom-Lemos Lde C, Barbosa FS, Passos LS, Gaze S, Carneiro CM, Bartholomeu DC, Bueno LL, Fujiwara RT

Parasitological and immunological aspects of early Ascaris spp. infection in mice.

Int J Parasitol. 2013;43(9):697-706 - PMID: 23665127 - DOI: 10.1016/j.ijpara.2013.02.009

Coelho-dos-Reis JG, Passos L, Duarte MC, Araújo MG, Campi-Azevedo AC, Teixeira-Carvalho A, Peruhype-Magalhães V, Trindade BC, Dos Santos Dias R, Martins ML, Carneiro-Proietti AB, Guedes AC, Gonçalves DU, Martins-Filho OA

Immunological profile of HTLV-1-infected patients associated with infectious or autoimmune dermatological disorders.

PLoS Negl Trop Dis. 2013;7(7):e2328 - PMID: 23936564 - PMCID: PMC3723575 - DOI: 10.1371/journal.pntd.0002328