Aikawa-Aikawa Laboratories

Collste O, Sörensson P, Frick M, Agewall S, Daniel M, Henareh L, Ekenbäck C, Eurenius L, Guiron C, Jernberg T, Hofman-Bang C, Malmqvist K, Nagy E, Arheden H, Tornvall P

Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging: results from the Stockholm Myocardial Infarction with Normal Coronaries study.

J Intern Med. 2012;273(2):189-96 - PMID: 22742529 - DOI: 10.1111/j.1365-2796.2012.02567.x

Nagy E, Eriksson P, Yousry M, Caidahl K, Ingelsson E, Hansson GK, Franco-Cereceda A, Bäck M

Valvular osteoclasts in calcification and aortic valve stenosis severity.

Int J Cardiol. 2013;168(3):2264-71 - PMID: 23452891 - DOI: 10.1016/j.ijcard.2013.01.207

Jensen AS, Johansson PI, Bochsen L, Idorn L, Sørensen KE, Thilén U, Nagy E, Furenäs E, Søndergaard L

Response letter to: "hypocoagulable" thromboelastography profiles in patients with cyanotic congenital heart disease: facts or technical artifacts?

Int J Cardiol. 2013;168(4):4426 - PMID: 23706329 - DOI: 10.1016/j.ijcard.2013.05.009

Labat C, Temmar M, Nagy E, Bean K, Brink C, Benetos A, Bäck M

Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis.

J Hypertens. 2013;31(11):2251-8; discussion 2258 - PMID: 23868086 - PMCID: PMC3819311 - DOI: 10.1097/HJH.0b013e328363dccc

Hutcheson JD, Maldonado N, Aikawa E

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.

Curr Opin Lipidol. 2014;25(5):327-32 - PMID: 25188916 - PMCID: PMC4166045 - DOI: 10.1097/MOL.0000000000000105

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E

Calcific Aortic Valve Disease: A Consensus Summary From the Alliance of Investigators on Calcific Aortic Valve Disease.

Arterioscler Thromb Vasc Biol. 2014;34(11):2387-93 - PMID: 25189570 - PMCID: PMC4199903 - DOI: 10.1161/ATVBAHA.114.302523

Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E

Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol.

J Extracell Vesicles. 2014;3:25129 - PMID: 25491249 - PMCID: PMC4261240 - DOI: 10.3402/jev.v3.25129

Fujita R, Tamai K, Aikawa E, Nimura K, Ishino S, Kikuchi Y, Kaneda Y

Endogenous Mesenchymal Stromal Cells in Bone Marrow are Required to Preserve Muscle Function in Mdx Mice.

Stem Cells. 2014;33(3):962-75 - PMID: 25408548 - DOI: 10.1002/stem.1900

Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, St?pie? E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS

EVpedia: a community web portal for extracellular vesicles research.

Bioinformatics. 2014;31(6):933-9 - PMID: 25388151 - PMCID: PMC4375401 - DOI: 10.1093/bioinformatics/btu741

Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E

Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease.

Am J Pathol. 2015;185(4):1156-66 - PMID: 25680278 - PMCID: PMC4380840 - DOI: 10.1016/j.ajpath.2014.11.026

Ruiz JL, Hutcheson JD, Aikawa E

Cardiovascular calcification: current controversies and novel concepts.

Cardiovasc Pathol. 2015;24(4):207-12 - PMID: 25797772 - DOI: 10.1016/j.carpath.2015.03.002

Lu H, Aikawa M

Many faces of matrix metalloproteinases in aortic aneurysms.

Arterioscler Thromb Vasc Biol. 2015;35(4):752-4 - PMID: 25810296 - DOI: 10.1161/ATVBAHA.115.305401

Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E

N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification

J. Cardiovasc. Dev. Dis. 2015;2(2):31-47 - PMID: 29371511 - PMCID: PMC5753093 - DOI: 10.3390/jcdd2020031

Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M

New CETP Inhibitor K-312 Reduces PCSK9 Expression: A Potential Effect on LDL Cholesterol Metabolism.

Am J Physiol Endocrinol Metab. 2015;309(2):E177-90 - PMID: 26015437 - DOI: 10.1152/ajpendo.00528.2014

Salinas M, Schmidt DE, Libera M, Lange RR, Ramaswamy S

Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations.

Comput Methods Biomech Biomed Engin. 2012;17(7):728-39 - PMID: 22920330 - DOI: 10.1080/10255842.2012.715157

Salinas M, Schmidt DE, Libera M, Lange RR, Ramaswamy S

Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations.

Comput Methods Biomech Biomed Engin. 2012;17(7):728-39 - PMID: 22920330 - DOI: 10.1080/10255842.2012.715157

Aikawa E, Fujita R, Kikuchi Y, Kaneda Y, Tamai K

Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFR?(+) mesenchymal cells from bone marrow.

Sci Rep. 2015;5:11008 - PMID: 26046579 - PMCID: PMC4457135 - DOI: 10.1038/srep11008

Aikawa E, Gardiner C, Hutcheson JD, Ochiya T, Osteikoetxea X, Pegtel M, Piper M, Quesenberry P, Schiffelers RM, Szabó TG, Buzas EI

International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013).

J Extracell Vesicles. 2013;2:23070 - PMID: 26082318 - PMCID: PMC3854124 - DOI: 10.3402/jev.v2i0.23070

Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.

PLoS One. 2015;10(7):e0131176 - PMID: 26132105 - PMCID: PMC4489192 - DOI: 10.1371/journal.pone.0131176

Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E

Valvular interstitial cells suppress calcification of valvular endothelial cells.

Atherosclerosis. 2015;242(1):251-260 - PMID: 26232165 - PMCID: PMC4546848 - DOI: 10.1016/j.atherosclerosis.2015.07.008

Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA

mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling.

J Proteomics. 2015;128:132-40 - PMID: 26232111 - DOI: 10.1016/j.jprot.2015.07.024

Rogers MA, Aikawa E

A Not-so-Little Role for Lp(a) in the Development of Calcific Aortic Valve Disease.

Circulation. 2015;132(8):621-3 - PMID: 26224809 - PMCID: PMC4550561 - DOI: 10.1161/CIRCULATIONAHA.115.018139

Singh SA, Miyosawa K, Aikawa M

Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease.

Expert Rev Proteomics. 2015;12(5):519-32 - PMID: 26325144 - DOI: 10.1586/14789450.2015.1078731

Hutcheson JD, Goettsch C, Rogers MA, Aikawa E

Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach.

Semin Cell Dev Biol. 2015;46:68-77 - PMID: 26358815 - DOI: 10.1016/j.semcdb.2015.09.004

Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E

Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease.

PLoS One. 2015;10(9):e0138047 - PMID: 26367531 - PMCID: PMC4569429 - DOI: 10.1371/journal.pone.0138047

Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.

Arterioscler Thromb Vasc Biol. 2015;35(11):2343-2353 - PMID: 26404485 - PMCID: PMC5003117 - DOI: 10.1161/ATVBAHA.115.305516

Wang JG, Aikawa M

Toll-Like Receptors and Src-Family Kinases in Atherosclerosis?- Focus on Macrophages.

Circ J. 2015;79(11):2332-4 - PMID: 26467082 - DOI: 10.1253/circj.CJ-15-1039

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH,

Mitral valve disease-morphology and mechanisms.

Nat Rev Cardiol. 2015;12(12):689-710 - PMID: 26483167 - PMCID: PMC4804623 - DOI: 10.1038/nrcardio.2015.161

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB

Insulin dissociates the effects of Liver X Receptor on lipogenesis, endoplasmic reticulum stress and inflammation.

J Biol Chem. 2015;291(3):1115-22 - PMID: 26511317 - PMCID: PMC4714195 - DOI: 10.1074/jbc.M115.668269

Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.

Nat Mater. 2016;15(3):335-43 - PMID: 26752654 - PMCID: PMC4767675 - DOI: 10.1038/nmat4519

Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E

Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-? Signaling.

Arterioscler Thromb Vasc Biol. 2016;36(3):525-33 - PMID: 26800565 - PMCID: PMC4767541 - DOI: 10.1161/ATVBAHA.115.307009

Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA,

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.

J Am Coll Cardiol. 2016;67(3):275-87 - PMID: 26796392 - PMCID: PMC5099077 - DOI: 10.1016/j.jacc.2015.10.092

Katsuki S, Ito K, Tadokoro T, Sasaguri T, Hisahara M, Mohri M

Mitral annulus calcification-related calcified amorphous tumour trapped and extended by closing aortic valve.

Eur Heart J Cardiovasc Imaging. 2016;17(5):585 - PMID: 26787612 - DOI: 10.1093/ehjci/jev349

Katsuki S, Matoba T, Nakashiro S, Sato K, Koga J, Nakano K, Nakano Y, Egusa S, Sunagawa K, Egashira K

Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes.

Circulation. 2013;129(8):896-906 - PMID: 24305567 - DOI: 10.1161/CIRCULATIONAHA.113.002870

Sato K, Nakano K, Katsuki S, Matoba T, Osada K, Sawamura T, Sunagawa K, Egashira K

Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.

J Atheroscler Thromb. 2012;19(11):986-98 - PMID: 22785139 - DOI: 10.5551/jat.13391

Katsuki S, Matoba T, Nakashiro S, Sato K, Koga J, Nakano K, Nakano Y, Egusa S, Sunagawa K, Egashira K

Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes.

Circulation. 2013;129(8):896-906 - PMID: 24305567 - DOI: 10.1161/CIRCULATIONAHA.113.002870

Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E

Extracellular vesicles in cardiovascular calcification: Expanding current paradigms.

J Physiol. 2016;594(11):2895-903 - PMID: 26824781 - PMCID: PMC4887674 - DOI: 10.1113/JP271338

Nakashiro S, Matoba T, Umezu R, Koga JI, Tokutome M, Katsuki S, Nakano K, Sunagawa K, Egashira K

Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice.

Arterioscler Thromb Vasc Biol. 2016;36(3):491-500 - PMID: 26821947 - DOI: 10.1161/ATVBAHA.115.307057

Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M

Multiple apolipoprotein kinetics measured in human HDL by high resolution/accurate mass parallel reaction monitoring.

J Lipid Res. 2016;57(4):714-28 - PMID: 26862155 - PMCID: PMC4808760 - DOI: 10.1194/jlr.D061432

Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

J Clin Invest. 2016;126(4):1323-36 - PMID: 26950419 - PMCID: PMC4811143 - DOI: 10.1172/JCI80851

Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA

3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.

Eur Heart J Cardiovasc Imaging. 2016;17(5):510-1 - PMID: 26976355 - PMCID: PMC4829123 - DOI: 10.1093/ehjci/jew029

Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.

J Mol Cell Cardiol. 2016;94:13-20 - PMID: 26996755 - PMCID: PMC4906202 - DOI: 10.1016/j.yjmcc.2016.03.004

Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD

Zooming in on the genesis of atherosclerotic plaque microcalcifications.

J Physiol. 2016;594(11):2915-27 - PMID: 27040360 - PMCID: PMC4887667 - DOI: 10.1113/JP271339

Decano JL, Mattson PC, Aikawa M

Macrophages in Vascular Inflammation: Origins and Functions.

Curr Atheroscler Rep. 2016;18(6):34 - PMID: 27125207 - DOI: 10.1007/s11883-016-0585-2

Aikawa E

Extracellular vesicles in cardiovascular disease: focus on vascular calcification.

J Physiol. 2016;594(11):2877-80 - PMID: 27246548 - PMCID: PMC4887668 - DOI: 10.1113/JP272112

Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J

Endophenotype Network Models: Common Core of Complex Diseases.

Sci Rep. 2016;6:27414 - PMID: 27278246 - PMCID: PMC4899691 - DOI: 10.1038/srep27414

O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.

J Vis Exp. 2016;(111):ePub - PMID: 27284788 - PMCID: PMC4927747 - DOI: 10.3791/54017

Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.

Atherosclerosis. 2016;251:109-118 - PMID: 27318830 - PMCID: PMC4983246 - DOI: 10.1016/j.atherosclerosis.2016.06.011

Mosch J, Gleissner CA, Body S, Aikawa E

Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.

Histol Histopathol. 2016;32(3):293-306 - PMID: 27353274 - PMCID: PMC5199639 - DOI: 10.14670/HH-11-797

Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA

Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis.

Circ Res. 2016;119(2):330-40 - PMID: 27390335 - PMCID: PMC4939871 - DOI: 10.1161/CIRCRESAHA.116.307971